The liver is an important organ for metabolism and detoxification of drugs and poisons, so the rational use of drugs for liver disease should be given more attention. Any toxic side effects of Chinese or Western medicine long-term use, regardless of its toxicity, may cause drug-related liver damage, thereby aggravating liver cell damage and necrosis, China’s drug-related liver damage cases at a rate of 3% to 4.5% increase, so the rational use of drugs is the first safe use of drugs. It is not advisable to rely on advertising information and look for medicine everywhere, which is not only costly but also a waste of money. Patients with hepatitis must choose their medication scientifically according to their condition, and it is best to go to a regular hospital to receive guidance from a specialist and regular checkups. The internationally recognized anti-hepatitis B virus drugs are alpha interferon (alpha-IFN) and nucleoside analogues such as lamivudine, adefovir, entecavir, etc. Immunomodulatory drugs such as α-thymidine and oxymatrine also have certain anti-hepatitis B virus effects. Commonly used hepatoprotective drugs mainly include anti-hepatocyte necrosis drugs, drugs to promote hepatocyte repair, detoxification and liver protection drugs. If laboratory tests show abnormal liver function tests, such as elevated serum transaminases, increased serum bilirubin, abnormal serum protein, suggesting liver cell damage, liver protection drugs can be used. Commonly used hepatoprotective drugs include: hepatocyte growth promoter, silymarin extract and its compound, glycyrrhizin, reduced glutathione, inosine, oleanolic acid, biphenyldiphenhydramine, dicyclomine, salvia preparations, etc. Commonly used anti-liver fibrosis drugs include interferon γ, compound bovine fetal liver cell extracts, mainly containing Danshen, Cordyceps sinensis herbal compound preparations, or blood activating and blood stasis removing Chinese patent medicines such as compound turtle nail soft liver tablets, Fu Zheng Hua Yu capsule, Anluo Hua Fibers pill, etc. The treatment of liver diseases with TCM is the characteristic and advantage of China, which has played a positive role in improving symptoms, reducing pain, complications and death rate, shortening hospitalization time and reducing medical costs for acute and chronic liver diseases. At present, the clinical application of both various forms of proprietary Chinese medicines, including injections, more oral agents and tonics. However, it is very common for patients with liver disease to seek medical treatment in a hurry, and some irresponsible medical advertisements have caused many patients to blindly seek “biased” and “secret” prescriptions, resulting in a large number of patients aggravating their conditions due to misdiagnosis and mistreatment. At the same time, reasonable care such as proper rest, reasonable diet, and maintaining mental health are also very important. Therefore, the disease itself is not terrible, what is terrible is to lose the confidence to overcome the disease and lose the courage to live. Do not easily listen to false advertisements, but go to a regular hospital and consult a specialist in time.