If you touch the hand of a syphilis patient, you will not get syphilis. This is because the causative agent of syphilis, both the syphilis spirochete, exists only in the skin lesions, blood, semen, breast milk and saliva of the patient, and only through the broken skin or mucous membrane of the uninfected person and into the body of the uninfected person will it cause disease, and the contagiousness of syphilis will increase as the patient is infected with Syphilis spirochetes become less and less contagious as the time after the patient is infected with them increases. Therefore, everyday ritualistic interactions, such as shaking hands, hugging, and eating, are not likely to contract syphilis. In the prevention and control of syphilis, it is necessary to pay attention to the prohibition of unprotected sex, multiple sexual partners and other high-risk sexual behavior, the prohibition of irregular blood transfusion, and the prevention and control of syphilis transmission from pregnant women who have syphilis to their fetuses.