Ketoacidosis in children may be related to infections or inappropriate use of insulin, etc. Treatment includes fluid therapy, control of the primary disease, and control of infections. Ketoacidosis in children is one of the common complications of diabetes mellitus in children, and treatment requires comprehensive treatment of hyperglycemia, dehydration, acidosis, electrolyte disorders, and possible infection. Fluid therapy mainly treats dehydration, acidosis and electrolyte disorders, following the principle of fast then slow, saline then sugar water to replenish blood volume and improve blood circulation and kidney function. Control of primary disease includes active control of hyperglycemic state, and after supplementation of water and insulin, blood glucose can be lowered and acidosis can be corrected, which can be treated with small-dose insulin intravenous drip. Ketoacidosis in children is often complicated by infection, which can be treated with effective antibiotics (cephalosporins, etc.) while correcting the acidosis. Ketoacidosis in children, it is recommended to consult a doctor in time, under the guidance of a professional doctor, standardized treatment. The medication should be administered according to the doctor’s instructions.