When precocious puberty occurs in children, Zhi Bai Di Huang Wan can be taken. This is because children with precocious puberty, especially pseudo-precocious puberty, will have the symptoms of yin deficiency and fire, and at this time children have a redder tongue and less tongue coating, and children will have premature breast development and premature menstruation. It can nourish yin and lower fire, which can help to relieve and subside the secondary sexual characteristics of children, so children with precocious puberty can apply Zhi Bai Di Huang Wan. If children’s precocious puberty belongs to true precocious puberty, with bone age significantly advanced by more than two weeks, this time should be combined with drugs such as Daphylline.