Drug fever (DF) is a fever caused directly or indirectly by the use of drugs, with a variety of fever patterns, and is one of the adverse effects of drug therapy. Common drugs that may cause fever: sulfonamides, amphotericin B, penicillin, ampicillin, penicillamine, bleomycin, vincristine, antihistamines, barbiturates, asparaginase, methyldopa, phenytoin sodium, procainamide, quinidine, salicylates, atropine, thyroxine, epinephrine, phenothiazines, acetazolamide, arsenic, laxatives, etc.; more common drugs that may cause fever Iodine, cephalosporins, isoniazid, sodium para-aminosalicylate, rifampicin, streptomycin, vancomycin, polymyxin E, adriamycin, allopurinol, azathioprine, cimetidine, codeine, hydralazine, furantoin, propylthioxypyrimethamine, streptokinase, heparin, finasteride, botrytisone, rimantadine, shark’s liver alcohol, metronidazole, levamisole, inflammation pain Xicam, etc.; Occasional fever-inducing drugs The drugs digitalis, insulin, chloramphenicol, tetracycline, etc. The mechanism of drug fever may be related to the following factors: (1) drug metabolic reaction: the drug as a total antigen or half antigen and the body protein binding can produce antibodies, antigen-antibody complexes can be phagocytosed to release endogenous pyrogen and cause fever in patients. (2) Specific reactions: caused by genetic defects, causing hemolytic anemia or pernicious hyperthermia when certain drugs are used. (3) Medication-related reactions, which can occur in any patient. (4) Pharmacological effects: drugs destroy and kill microorganisms or cells, producing endogenous pyrogenic sources; fever can also occur from bleeding caused by massive application of anticoagulants. (5) The drug affects the thermoregulatory mechanism, including the effect on the thermoregulatory center, basal metabolism, glandular secretion, etc. Generally speaking, drug fever can be diagnosed by meeting 2 of the following conditions: after the application of antibiotics for infectious fever, the body temperature drops once, and then continues to use the drug, the body temperature rises again or the body temperature is higher than before the application of antibiotics, which cannot be explained by the original infection, and no other cause can be found, while the patient’s general condition is still acceptable; fever occurs after the application of drugs for patients with non-febrile diseases, which cannot be explained by secondary infection. Rapid decrease in body temperature after discontinuation of the suspected drug. The temperature profile of drug fever is not regular and can occur in any fever type. It takes about a week for the drug antigen or semi-antigen to be excreted in the body or eliminated by the monocyte macrophage system, so most patients’ body temperature can return to normal within 24-48 hours, usually no more than 1 week. There are also cases with longer recovery time, which may be due to liver and kidney impairment, delayed drug metabolism and excretion. In the past, about half of the drug fever cases only showed simple fever without other concomitant symptoms, and the most common fever type was flaccid fever, and the time to return to normal temperature after stopping the drug was 1-6 days, and 90% of the patients could return to normal temperature 3 days after stopping the drug. Wang Junyu et al. reported a case of a patient with gout disease who had recurrent fever with rash caused by taking allopurinol and deprenyl tablets, and the body temperature gradually decreased to normal 11 days after stopping the suspected drugs. In patients diagnosed with drug fever, all suspected drugs should be discontinued; rehydration and drug excretion should be promoted; clinical symptoms should be relieved and complications should be prevented and treated; adrenaline corticosteroids should be used in severe cases, but it should be borne in mind that hormones can cause drug fever. It is important to note that calcium, antihistamines, and antipyretics can also cause drug fever, and their use is therefore not recommended. Drug fever has a variety of immune mechanisms involved in the pathogenesis, and traditional Chinese medicine may have a regulatory role in the multiple links of drug-induced fever. Treatment of drug fever should be evidence-based and give full play to the advantages of traditional Chinese medicine, clearing heat and cooling the blood: raw earth, red peony, salvia, etc.; clearing heat and detoxifying fire: honeysuckle, gong ying, raw gypsum; nourishing yin and generating fluid: sage, yu zhu, maitong, turtle nails, etc.; clearing deficiency heat: artemisia, ground bones, etc.; dispelling wind and relieving itching: Fangfeng, Dioscorea, Chuanxiong, Guizhi, Cicada, etc. Due to the abuse of drugs, especially antibiotics, the proportion of drug fever in febrile patients is on the rise. On the one hand, we are reminded to use drugs rationally, on the other hand, the importance of drug fever should be increased, early detection and timely treatment.