The swelling of the face of patients with nephrotic syndrome is mainly related to the hypoproteinemia caused by the primary disease. Patients with nephrotic syndrome will mainly have significant hypoproteinemia, massive proteinuria and edema, and some will also have hyperlipidemia, which are the four main manifestations. The main reason is that this disease causes damage to the glomerular filtration membrane of the kidney, which results in a large amount of protein loss from the urine, and gradually the albumin in the blood decreases and is significantly lower than the normal value. When the albumin in the blood is significantly lower, it causes a decrease in the colloid osmotic pressure in the blood vessels, so that the components of the plasma in the blood vessels will significantly leak out into the subcutaneous tissue. The face and eyelids are relatively lax tissues, so the extravasation of plasma into the interstitial fluid is often more pronounced in the face, and in some cases it is accompanied by edema in both lower extremities. Therefore, the treatment of this type of disease needs to control a large amount of proteinuria at the root, and the protein in the blood will increase significantly after the proteinuria is reduced, so that the edema may be reduced after the plasma colloid osmotic pressure is increased.