Ms. Li of Longmen Scenic Area asked: My husband has been suffering from indigestion for more than 1 year, for a long time no appetite, bloating abdominal pain, constipation and diarrhea alternately, weight loss from 70 to 54 kg, we ran a number of hospitals, did a full body examination are no organic pathology, but he is in a bad mood, insomnia, no energy, the thought of a long time to cure, you want to ” Someone suggested to see a psychiatrist, but he thinks he has no psychological problems, so what should we do? I believe that many specialists will encounter such a similar inquiry. Ms. Li’s husband has chronic “indigestion” and has had numerous laboratory tests with no positive findings, but he is depressed and even has pessimistic thoughts, and is considered to be suffering from “depression”. Patients with depression can have a variety of physical symptoms, but the real depressive symptoms are mostly hidden behind a wide range of complaints, making it difficult to recognize the true nature of their hut. The physical symptoms are mostly related to the digestive system, cardiovascular system and pain, followed by the respiratory system and genitourinary system. The common complaints include “nausea and vomiting, abdominal distension and pain, constipation and diarrhea, gas moving around in the abdomen”, “inexplicable panic, anxiety all day long, fatigue and chest pain”, “wandering symptoms”, and “depression. “, “wandering headache, neck pain, often intermittent leg pain”, “urinary frequency and urgency” and so on. These various complaints are often misdiagnosed as gastritis, enteritis, hyperthyroidism, vascular headache, arthritis, plant nervous disorder, etc. The general sedative and sleeping, anti-inflammatory and analgesic drugs or blood nourishing and tranquilizing drugs have little effect, but after giving psychotherapy with antidepressants, they can mostly be well controlled. According to clinical observation, in recent years, the typical three low type of depression (slow thinking, low emotion, low will) has become rare, and the depression with physical symptoms of various disciplines is increasing day by day, these patients will not cause “gibberish” nor cause obvious behavioral disorders, but it makes patients feel both mental and physical pain, and the surface looks normal. They are often misunderstood by friends, relatives and colleagues as “not sick” or “not sick pretending to be sick”. Therefore, they are very sensitive to the words of others, and are grateful for the sympathy of others. Therefore, doctors and friends around should give more love, care and patience to make them get rid of depression as soon as possible.