Syphilis is a chronic systemic sexually transmitted disease caused by the syphilis spirochete (also known as the pallid spirochete), which attacks not only the skin and mucous membranes, but also various organs throughout the body, producing a variety of symptoms and signs. According to the length of the disease, it is divided into early syphilis and late syphilis. Early syphilis includes stage I syphilis, stage II syphilis and early latent syphilis. Those who have been sick for more than 2 years are called advanced syphilis. I, the principles of syphilis treatment: 1, the earlier the treatment, the better the effect; 2, the treatment must be regular, sufficient amount, full course; 3, after treatment to be regular follow-up after sufficient time; 4, the source of infection and its sexual partners must be examined and treated at the same time. Second, the treatment plan is mainly to choose benzathine penicillin G 2.4 million U, divided into two sides of the buttocks intramuscular injection, 1 time / week, a total of 3 times. Patients with penicillin allergy can choose to take oral tetracycline or erythromycin, and the course of treatment varies according to different stages. Syphilis should be followed up for 2-3 years after timely and standardized treatment. A timely visit should be made 3 months after the end of treatment for testing of RPR to understand the progress of the disease and the effectiveness of treatment, etc. The test should be repeated every 3 months in the first year and every 6 months thereafter, including clinical and serum (non-spirochete antigen test, or RPR). Patients with neurosyphilis are followed up with CSF (cerebrospinal fluid examination) every six months until CSF completely turns normal. If the serum titer does not decrease 4-fold within 6 months after treatment, it should be considered a treatment failure or reinfection, and in addition to the need for retreatment, the need for a cerebrospinal fluid test should be considered to observe the presence of syphilis infection in the nervous system. Generally, it is normal for Phase I syphilis to turn negative within 1 year and Phase II syphilis within 2 years. It should be noted that sexual partners must be examined and treated at the same time. During the period of syphilis treatment and follow-up tests are still positive, sexual intercourse should be avoided because it is still contagious and further avoids the possibility of reinfection before cure, which can interfere with the evaluation of the treatment of the initial infection. For the health of you and your family, I hope you must insist on follow-up visits and find any problems to consult your doctor in time to avoid delays in treatment, syphilis is generally better after timely detection and standardized treatment.