There are many factors that affect the occurrence and development of diabetic nephropathy. Proteinuria is a risk factor for the development of diabetic nephropathy and cardiovascular disease, and reducing proteinuria can delay the progression of renal damage, so it should be one of the main goals of clinical treatment; 2, hyperglycemia is the root cause of target organ vascular complications, including diabetic nephropathy, and strict control of blood glucose can delay the progression of renal damage; 3, hypertension The incidence of hypertension in patients with diabetic nephropathy The incidence of hypertension in patients with diabetic kidney disease is significantly increased, and strict control of hypertension can delay the progression of kidney damage; 4, lipid metabolism disorders Lipid metabolism disorders are common in patients with diabetic nephropathy, especially in patients with nephrotic syndrome, hyperlipidemia itself can lead to kidney damage and aggravate diabetic kidney disease; 5, smoking smoking is an independent risk factor for diabetic nephropathy and cardiovascular disease, which can aggravate the kidney damage of diabetic nephropathy; 6, high protein intake high Protein intake can lead to increased urinary protein excretion; 7, visceral obesity Type 2 diabetes patients are often combined with obesity, it is believed that visceral obesity is closely related to insulin resistance, and visceral obesity can also cause kidney damage, may also be involved in the development of diabetic nephropathy in patients with type 2 diabetes.