Diabetic nephropathy is a very serious complication of diabetes, and exercise is an important non-pharmacological treatment for diabetes. So how can exercise treat and reverse diabetic nephropathy? Increased physical activity in patients with type 2 diabetes can reduce the risk of chronic kidney disease and even reverse impaired kidney function, according to recent expert panel findings from the International Society of Endocrinology 2014 Annual Meeting. However, the type of exercise, how much exercise, and the duration of exercise are tailored to each diabetic patient. Exercise intensity is the most important indicator in the exercise treatment of diabetic nephropathy. In the study of exercise therapy for diabetic nephropathy in which scientists from several countries participated, a total of 5700 type 2 diabetic patients with normal kidney function, with an average age of 61±10.3 years, were included and all had passed the exercise load test. Patients were classified by activity intensity to determine the metabolic equivalent of energy (MET): lowest intensity (<5.5 METs), low intensity (5.5-7.5 METs), moderate intensity (7.6-9.5 METs), and high intensity (>9.5 METs). As activity intensity increased, patients’ CKD prevalence and risk of death gradually decreased. The researchers said that a sharp decrease in CKD prevalence occurred as the patients’ activity intensity ranged from the lowest to the lowest. This suggests that exercise intensity is an important factor in reducing the risk of developing diabetic nephropathy and reducing symptoms and reversing indicators. Among the exercise therapies for diabetic nephropathy, individualized adjustment of the number and duration of exercise is the second most important factor in regulating glomerular filtration rate (eGFR) and controlling and reversing diabetic nephropathy. This Diabetic Nephropathy Exercise Therapy Reversal Study evaluated the effect of exercise frequency and duration on glomerular filtration rate (eGFR). Researchers evaluated patients who completed 12 weeks of aerobic or endurance training, testing peak exercise capacity, biochemical markers and blood pressure at baseline and at the end of the exercise program, respectively. Patients were shown to have changes in exercise capacity and eGFR at the end of the exercise program as well. The results of these diabetic nephropathy exercise therapy studies suggest that enhancing cardiorespiratory fitness is an important non-pharmacological adjunct to the treatment of renal insufficiency. The exercise measurement and adjustment program developed by a team of experts from different disciplines (endocrine, renal, exercise, cardiac, etc.), according to each patient’s condition, together support that a gradual increase in the number and appropriate duration of exercise is an effective way to control and reverse diabetic chronic kidney disease, according to each patient’s condition.