Depression can be cured, and about 70%-80% of patients with first-episode depression will achieve a clinical cure, meaning that the depressive symptoms basically disappear or disappear completely, and the patient’s social functioning returns to normal, allowing him/her to engage in normal life, study, work and social interaction. However, depression is a disease prone to relapse, and more than half of the patients with first-episode depression experience a relapse within 5 years, so even if cured, it is still important to actively prevent relapse. Relapse prevention can be achieved by: 1) adhering to adequate doses of antidepressants; 2) adhering to antidepressant treatment for a long enough period of time; and 3) engaging in psychological support therapy.