Scleroderma is a systemic autoimmune disease characterized by tight and hard skin. And mixed connective tissue disease is an autoimmune disease characterized by tight finger skin, like salami, white and purple fingers, with Raynaud’s phenomenon, but also lung, heart and even kidney damage, the cause of the above two diseases is unknown, and may be related to genetics and immune dysfunction. Although the disease can not be cured, regular long-term treatment can make the majority of patients can be effectively controlled, so that the scleroderma lesions do not progress or partially recovered, to protect the function of the organs and improve the quality of life of patients. Treatment goals: 1.Stop disease progression 2.Partial reversal of the disease I. Intensive treatment (in the shortest possible time to achieve the above treatment goals) 1.Hormones Prednisone, dexamethasone, methylprednisolone, etc. Features: as a bridge treatment is a necessary means, can quickly improve some of the symptoms, but to bear more side effects, high dose use as short as possible, as early as possible to reduce the drug. 2.Intravenous gammaglobulin Features: Immunosuppression is fast-acting and has the effect of increasing the patient’s ability to resist disease. It is often used in critically ill patients, such as those with important organ damage, low immune function and significantly reduced platelets. 3.Immunosorbent and plasma replacement Characteristics: Fast-acting, but easy to rebound and expensive. It is an alternative for critically ill patients, such as those with important organ damage, organism immunocompromised and significantly reduced platelets, and often plays a crucial role. Second, long-term treatment (small dose long-term treatment) 1, hormones Prednisone, methylprednisolone, etc. Features: Intensive treatment for 1 to 2 months after the doctor’s guidance can be reduced until a small dose (5-10mg) long-term maintenance. 2. Immunosuppressants Cyclophosphamide, vincristine, leflunomide, mycophenolate, methotrexate, azathioprine, hydroxychloroquine sulfate, tacrolimus and cyclomycin, etc. Features: slow onset of action, need to cycle combined long-term medication, but the dose and interval of medication can be adjusted according to the changes of the disease and immune function, in principle, the minimum dose, the minimum number of times to maintain, to be observed in long-term follow-up. Follow-up plan: Close follow-up is the key to the treatment of scleroderma, in principle, patients must be followed up once in “three weeks”. The follow-up period can be appropriately extended according to the condition of the patient after 1 year of treatment. Note: 1. Functional exercise 1. Improve the level of biological hormones in the patient’s body, which can play a certain therapeutic role and reduce the amount of medication. 2.Prevent osteoporosis 3.Maintain and improve joint function 4.Enjoy mood and enhance physical fitness Exercise method: choose one of the ways 1.Swimming 1000 meters continuously every day (can be gradual) 2.Walking 1 hour a day (continuous) 3.Running 30 minutes a day (continuous) 2.No special contraindications on diet, but should avoid taking immunity-enhancing health products or proprietary Chinese medicine. Third, female patients with fertility needs should stop using immunosuppressive drugs for six months before pregnancy, and the whole process of pregnancy should be closely followed.