Disulfiram-like reaction, also known as withdrawal sulfur-like reaction, is a toxic reaction caused by the accumulation of acetaldehyde in the body due to the consumption of alcoholic beverages (or exposure to alcohol) after the application of drugs (cephalosporins, etc.). After alcohol enters the body, it is first oxidized to acetaldehyde by the action of “ethanol dehydrogenase” in the liver cells, and acetaldehyde is oxidized to “acetic acid and acetaldehyde” by the action of “acetaldehyde dehydrogenase” in the mitochondria of liver cells. Acetaldehyde is oxidized to “acetic acid and acetalase A” in the mitochondria of hepatocytes, and acetic acid is further metabolized to carbon dioxide and water and excreted from the body. Due to the presence of “methylthiotetrazolium side chain” in some chemical structures, the activity of acetaldehyde dehydrogenase in the mitochondria of hepatocytes is inhibited, which prevents further oxidation and metabolism of acetaldehyde after it is produced, resulting in the accumulation of acetaldehyde in the body and a disulfiram-like reaction. It manifests as chest tightness, shortness of breath, laryngeal edema, cyanosis of the lips, dyspnea, increased heart rate, decreased blood pressure, weakness of the limbs, facial flushing, excessive sweating, insomnia, headache, nausea, vomiting, blurred vision, drowsiness, hallucinations, trance, and even anaphylactic shock with a drop in blood pressure to 60-70/30-40 mmHg with loss of consciousness. It is easily misdiagnosed as acute coronary syndrome, heart failure, etc. In addition, the severity of disulfiram-like reactions is directly proportional to the dose of applied drugs and the amount of alcohol consumed. Drinking liquor is more severe than beer and alcoholic beverages, and drinking alcohol during drug administration is more severe than drinking alcohol after drug discontinuation. Drugs that cause disulfiram-like reactions include cephalosporins and imidazole derivatives, such as ceftriaxone sodium, cefoperazone, cefotaxime, etc.; in addition, metronidazole (metronidazole can inhibit the metabolism of alcohol, and drinking alcohol after taking the drug may cause abdominal pain, vomiting, headache and other symptoms), tinidazole, ketoconazole, furazolidone, chloramphenicol, methanesulfonylurea, glibenclamide, phenelzine, etc. can cause disulfiram-like reactions.