Gout is an ancient disease that was known to occur in the court of “dignitaries” and sexually mature men. The disease was known to occur in men who were sexually mature and who were courtly “dignitaries”. It was easily caused by overeating or sexual excess. In the 17th century, a crystalline form of gout nodules was seen in the microscope, and after 1847, urine salts were detected in the blood, subcutaneous tissue and joint cartilage deposits of gout patients. At the end of the 19th century, scientists further discovered that uric acid is produced by the oxidative metabolism of purine bases in the human body. In mammals in general, uric acid can be broken down into other products catalyzed by uricase. However, in humans, birds and reptiles, the “Creator” did not give this enzyme, so uric acid in the human body becomes the end product of purine substrates, so hyperuricemia and gout are easy to become the “patent” of people, normal people produce uric acid every day mainly by When uric acid is excreted by the kidneys, excessive uric acid production or excretion disorders can easily lead to increased blood uric acid and gout. Obesity, overnutrition, high blood fat, diabetes, hypertension, atherosclerosis, etc. are likely to trigger gout. Why was gout more common in ancient times among the “dignitaries”? Why is the incidence of gout increasing with economic development and affluence? We can find the answer to this question. When blood uric acid levels increase, uric acid is deposited in a variety of tissues, and joints and cartilage are the major accumulators of uric acid salts. The patient feels severe pain in these joints at night, which subsides on its own after three to five days. When gouty arthritis is prolonged, there are large deposits of uric acid in the joints and adjacent tissues, which are medically known as gout stones. This can lead to joint destruction and deformity and impaired movement. If the doctor takes a cursory history and is negligent in physical examination, it is often misdiagnosed as rheumatoid arthritis or other polyarticular diseases. When blood uric acid is excessively or persistently increased, the uric acid flowing through the kidneys in acidic urine will be deposited in the kidneys and the kidneys will be destroyed, called gouty nephropathy. Some people do not have conscious symptoms, but find abnormalities when they have urine tests. Severe and advanced patients eventually develop uremic syndrome, and about 20% of patients have complications with uric acid stones, which may present with renal colic, hematuria or uric acid stones with fish roe like crystals excreted in the urine. For those who drink alcohol regularly; for those who prefer large fish and meat and are obese and overweight, especially middle-aged men; for those who have recurrent joint pain, especially multiple small arthritis; don’t forget to monitor blood uric acid regularly. Because elevated blood uric acid is the earliest diagnostic evidence of gout. Early diagnosis and timely treatment will prevent internal organs from being invaded. Otherwise, if the disease is prolonged and the organs are damaged, it will be much more difficult to treat, and even irreversible lesions will be formed.