With the liberalization of the two-child policy, many families are facing the problem of having children. Many women with syphilis also have plans to become mothers. So, is it possible to get pregnant with syphilis? What do you need to do to prepare? 1, patients who have been infected with syphilis, as long as the regular treatment, re-examination RPR indicators have turned negative, or although not turned negative but maintain a low titer for a long time, can be considered to have children. Syphilis infection should receive regular treatment, and regular follow-up after regular treatment, that is, every three months in the first year after treatment, and every six months after one year, for two years. 2. If pregnancy is planned, a non-syphilis spirochete antibody serological test (RPR or TRUST) should be done at least 1 month before pregnancy to compare with previous results. If the non-syphilis spirochete antibody serologic test changes from negative to positive, or if the titer increases by more than 2 dilutions (e.g., from 1:2 to 1:8) (both of which are considered serologic relapses), or if there is a recurrence of clinical symptoms, treatment should be repeated or extended (2 courses of treatment with a 2-week interval). 3, a very small number of patients will appear after the regular anti-syphilis treatment, non-syphilis spirochete antibody titer down to a certain level that no longer fall phenomenon, and maintain this state for a long time, we call “serological fixed”. However, it should be noted that in this case, the titer of non-syphilis spirochete antibodies does not exceed 1:8, which may be caused by incomplete medication or irregular treatment, and may be followed by a course of treatment and, if necessary, testing of the cerebrospinal fluid, cardiovascular system, and HIV antibodies. If these are negative and after regular treatment, even if the non-syphilis spirochetes are not negative, the above-mentioned patients can prepare for pregnancy. If RPR remains negative during pregnancy, no treatment is needed. If RPR remains positive, it is best to repeat treatment, and two courses of long-acting penicillin treatment can be given during the first and second trimesters of pregnancy, that is, during the 0-3 months and the 7-10 months of pregnancy, for three weeks each time, with one long-acting penicillin injection per week. 5.Regardless of formal anti-syphilis treatment, in principle, it is recommended to test for TRUST or RPR once a month during pregnancy. 6.On the day of birth, cord blood is drawn for syphilis testing of the child.