Each attack lasted about 30 minutes and was accompanied by bulbar conjunctival congestion on the affected side. The nature of the pain was flaccid. The peak pain was always confined to the frontotemporal region of the affected side, and the interval between attacks was between 12 and 24 hours, with no abnormality between attacks. The patient complained of a history of similar headache attacks 6 years ago and no further attacks for several years after treatment with neurological drugs. Examination: generally acceptable, soft neck, pressure pain in the affected mastoid process (-), pressure pain along the right superior orbital rim (±) Auxiliary examination: no abnormality on CT plain scan of the head Diagnostic treatment: pterygopalatine ganglion block was effective during the attack. Diagnosis: Cluster headache Treatment: Considering that the patient is currently not suitable for medication during lactation, the treatment plan was based on sympathetic nerve function regulation and pterygopalatine ganglion block, and a stellate ganglion block was given to the affected side with 0.25% bupivacaine and 6 ml of 1:200,000 epinephrine injection. The interval between attacks was prolonged and the duration of attacks was shortened. The patient was advised to give a pterygopalatine ganglion block (head tilted back 40 degrees in a lying position and rotated 40 degrees to the affected side, 2% lidocaine 1 ml dripped through the nasal cavity of the affected side) within the first hour of the attack. Continue to maintain the original treatment regimen. Treatment goal: To give a stellate ganglion block on the affected side between headache attacks, once or twice a week until the headache symptoms have completely disappeared. Differential diagnosis: In generalized migraine, the headache begins as a dull pain in the supraorbital, retroorbital, or frontotemporal region of one side, which grows in intensity to a throbbing nature and then persists as a severe, fixed pain that extends over the entire half of the head and even the upper neck. The patient is pale, often with nausea and vomiting, and the headache usually lasts all day and is often terminated by sleep. The headache is often preceded by prodromal symptoms and is mostly bilateral, usually with onset in adolescence and most often with a family history. There is a slight increase in histamine and a significant decrease in pentazocine (5-HT). The headache disappears after pregnancy and recurs after delivery. The pain attacks last from 6 to 24 hours each time and are often preceded by cerebellar symptoms such as tinnitus and vertigo, visual aura such as flashes of light and hemianopia, and severe occipital pain lasting several minutes, often throbbing and accompanied by nausea and vomiting. The pain is often accompanied by dizziness and drowsiness during the interictal period and can be partially relieved after rest. The diagnosis of this case was initially inclined to migraine, but the patient’s headache attacks were short in duration and not accompanied by aura symptoms, and almost every attack was awakened in sleep with pain. Although cluster headache is more common in male patients, the characteristics of the female patient were consistent with cluster headache in terms of attack duration, attack location and conjunctival congestion. Whether it is migraine or cluster headache, evidence of vasomotor dysfunction can always be found during the attack. Modulation of sympathetic nerves by stellate ganglion block can effectively relieve various diseases or pain symptoms supported by sympathetic tone, especially various headaches highly related to abnormal vascular function, which is a proven treatment method.