Should I be treated for positive hepatitis B virus DNA? If hepatitis B virus DNA is detected in the body, regardless of other hepatitis B markers (positive or negative), the person is identified as having hepatitis B virus infection and his or her blood and body fluids are highly infectious. So should I be treated in this case? The significance of hepatitis B virus DNA test: Hepatitis B virus DNA is the deoxyribonucleic acid of the hepatitis B virus. Hepatitis B virus DNA is the most direct, specific and sensitive indicator of HBV infection. Hepatitis B virus DNA measurement is the best indicator to directly reflect the replication status and infectiousness of HBV, and plays a major role in the treatment of hepatitis B. The amount of hepatitis B virus DNA can directly reflect the amount of virus present in the body, whether it is infectious, and how strong it is. Positive hepatitis B virus DNA indicates HBV replication and infectiousness. High hepatitis B virus DNA indicates the more viral replication and infectiousness. Understanding how to treat positive hepatitis B virus DNA requires a comprehensive analysis in conjunction with liver function, ultrasound, liver puncture and other test results. For patients with normal liver function but positive hepatitis B virus DNA, if the ultrasound is normal and liver puncture shows no liver inflammation, some immune-boosting and liver-protective treatment is sufficient. If there is significant inflammatory activity in the liver antiviral treatment is needed if the ultrasound of hepatitis B virus DNA positive patients suggests cirrhosis, or if liver puncture test results show inflammation in the liver, even if liver function is normal, antiviral treatment is needed. Long-term liver inflammation can lead to the development of liver fibrosis, and the accumulation of liver fibrosis to a certain extent can lead to cirrhosis and even liver cancer. Therefore, it is very important for patients with positive hepatitis B virus DNA but normal liver function to undergo liver aspiration to clarify the presence of inflammation in the liver.