What is the TCM pathogenesis of diabetic foot? Diabetic gangrene is a chronic progressive clinical manifestation affecting large, medium, small and microvasculature, mostly thought to be due to limb ischemia, neuropathy, infection, metabolic disorders and multiple predisposing factors. Its local symptoms are mostly wet jaundice, which is extensive and rapidly developing, and systemic symptoms. According to the characteristics of diabetic gangrene, which occurs in the toes and plantar extensor and flexor tendons, the fascia is degenerated, the local skin blisters dry and black, the tendons are necrotic and sore, and the tendons are rotten like flocculent, but the ischemic pale purple is lighter, it is proposed that the disease is caused by disorders of pancreatic islet cell function and glucose metabolism, resulting in nerve degeneration of the terminal tendons, which is the “gangrene of tendons” of thirst, and its cause is the long-suffering Qi The disease is caused by the deficiency of both qi and yin, and the loss of nourishment of the tendons; high blood sugar is sweet, and the internal dampness grows, paralyzing the tendons with dampness, and the heat of depression for a long time will rot the tendons into gangrene. If the rotten tendons do not go away, the poisonous evil will be easily trapped in the camp blood, leading to “dirty failure” malignant symptoms and life-threatening; this disease is a heat evidence, Yang evidence, based on the lack of Qi and Yin, dampness and heat tendon rot as the standard.