Colorectal cancer is a malignant tumor with high incidence rate in China, and it is one of the “four major killers” of malignant tumors in digestive system together with stomach cancer, esophageal cancer and liver cancer. In recent years, radical surgery for colorectal cancer has become more and more standardized and refined with the efforts of surgeons, but only about 60% of patients can survive for more than 5 years after surgery, and liver metastasis is the most important problem affecting the long-term survival of colorectal cancer patients. Indeed, half of the patients will develop liver metastasis sooner or later after surgery, and this percentage is very high. Because all the blood in the gastrointestinal tract flows to the liver, so if the tumor penetrates the blood vessel wall during growth, there will be cancer cells running to the liver with the blood flow to be planted down, and metastatic cancer within the liver can be easily formed. However, fortunately, the growth rate of liver metastases of colorectal cancer is relatively slow, and only isolated metastatic foci are usually formed in the liver, and seldom continue to spread in the liver, which creates conditions for surgical resection. It has been 70 years since the first case of rectal cancer liver metastasis resection in 1940, and the actual efficacy has proved that surgical resection is still the most effective treatment for liver metastasis of colorectal cancer, and it is also the only way that can really cure the tumor. 40-50% of patients with liver metastases that can be surgically resected can have long-term survival. In other words, the presence of liver metastasis in colorectal cancer patients does not mean the end of the world or the beginning of the countdown of life. On the contrary, through active, scientific and targeted treatment, it is entirely possible to overcome colon cancer completely with the efforts of all of us. In the past 70 years, due to the great progress of surgical technology and the accumulation of experience of our hepatobiliary surgeons, the size, number, and location of liver metastatic cancer in the liver are no longer the factors affecting whether a patient can be operated or not, and a lot of forbidden zones of surgery in the past have been broken through one by one. It can be said that as long as enough liver can be preserved after surgery (usually more than 30%), most of the liver metastases can be resected. If there are metastases outside the liver, those that can be removed can also be removed, such as lung metastases, abdominal implant metastases, metastatic lymph nodes in the liver hilum, and so on, can be removed. Some patients are found to have liver metastasis at the same time when they are found to have colorectal cancer, which should be treated separately according to the situation. If the patient’s liver function and physical condition allow, according to the current technology, the tumor can be removed at the same time in one operation. If emergency surgery is needed due to the tumor blocking the intestinal tract, due to the lack of perfect preoperative examination data and the high chance of surgical infection, we do not recommend the simultaneous resection of metastatic cancer, and priority should be given to ensure the smooth resection of primary colorectal cancer and the rapid recovery of the patient. Within 2 years after resection of liver metastatic cancer, recurrence may occur in 60% of the cases, and about 1/3 of the cases still appear in the liver. Don’t be discouraged and don’t be afraid, as long as the condition permits, it is still able to be treated by surgery again, and the overall survival after re-resection is similar to the initial liver resection. Of course, surgery is not a panacea, and in the face of a formidable enemy we surgeons need reinforcements, that is, a multidisciplinary integrated treatment. For example, preoperative and postoperative radiotherapy and chemotherapy are used, and different regimens are chosen for different patients. For those patients who can not open surgery can also use less invasive radiofrequency or microwave ablation methods, with a long needle outside the body (without open surgery) can destroy certain parts of the smaller size of liver metastatic tumor. Therefore, when colorectal cancer patients have liver metastases, they should not be desperate and pessimistic, and they should know that this is a disease that has a chance to be cured. What you have to do is not to consult doctors when you are sick and look for secret prescriptions everywhere, but you should go to a regular professional hepatobiliary surgeon in time and actively strive for the chance of treatment. We will help you through this together, you are not alone in this fight!