I. Acute treatment Low purine diet, avoid alcohol, avoid excessive hunger; drink more water (more than 2500ml), so that the daily urine volume is not less than 2000ml to promote uric acid excretion; joint braking and warmth to avoid re-injury induced acute attacks; do not add uric acid-lowering drugs such as allopurinol and benzbromarone during the acute period, otherwise it may lead to recurrent attacks and prolonged treatment; but do not need to stop the original long-term use of uric acid-lowering drugs; add sodium bicarbonate tablets in 3 doses to alkalize the urine to prevent the formation of urinary pH 6.2-6.9; add anti-inflammatory tablets to alkalize the urine to prevent the formation of urinary tract stones. Add sodium bicarbonate tablets 3-6g/d in 3 doses to alkalize the urine and prevent the formation of urinary stones, so that the urine pH is 6.2-6.9; add anti-inflammatory and analgesic drugs to promote the relief of joint inflammation, such as etoricoxib 120mg 1/day or ibuprofen 0.4 3/day, etc.; in patients with clear chronic renal insufficiency, glucocorticoid therapy or only topical drugs can be used. Topical medication can be chosen from Fotarine emulsion, Piroxicam patch or Ketoprofen patch; choose colchicine to terminate the seizure: within 24 hours of the seizure, preferably within 6 hours is good, 2 tablets (0.5mg/tablet) are taken immediately when the seizure is found, and 1 tablet is taken 1 hour later; after 12 hours, 1 more tablet can be taken if necessary. Thereafter, take 1 tablet 2 to 3 times per day, no more than 3 times per day, until symptoms resolve. The duration of treatment should not exceed two weeks. The dosage should be reduced in cases of renal insufficiency. Initial gout in arthritis remission 2 weeks after the formation of hyperuricemia according to the cause of the choice of uric acid-lowering drugs; gouty arthritis can be remitted on its own in 3 to 10 days, please do not use antibiotics at will, the treatment is meaningless for gout. Second, remission treatment Purpose: to control gout attacks and reduce the risk of hypertension, cardiovascular disease and kidney damage caused by hyperuricemia; Requirements: the first step to reduce blood uric acid to below 360umol/L continuously, and 1~2 months later to below 300umol/L continuously; Abdominal obesity leading to insulin resistance is the basis for the development of most gout. Efforts to reduce body weight to improve insulin resistance may be the pathway to radical improvement of the condition. Weight loss may also reduce hypertension, hyperlipidemia, fatty liver, diabetes mellitus, and coronary heart disease. In obese people, obesity brings more diseases. Weight loss can reduce medication and even cure itself, so weight loss is the way out! Note: After 1 week of relief of joint pain, keep 24-hour urine at home and record 24-hour urine volume, and take 5ml of mixed urine for 24-hour urine protein, creatinine, and uric acid test; take blood for blood uric acid and kidney function on the day of urine test on an empty stomach, and check blood routine, liver function and blood lipid; urological ultrasound; take febuxostat, allopurinol, benzbromarone, fenofibrate and other drugs, all need to regularly review blood routine and liver and kidney If you take allopurinol, check HLA-B5801, gradually increase the dose from small to 300mg, and pay special attention to skin changes. If you experience itching, rash, sore throat, fever, etc., you should immediately stop taking the above drugs and review blood tests. The same is true for those who need to drink more water.