Acanthosis nigricans and adolescent obesity During the winter and summer holidays, many parents often bring their children to the hospital to see obesity, mostly complaining that their children’s appetite is too big, very easy to starve, always can not eat enough, study energy is not concentrated, some also appear emotional instability, some have appeared elevated blood lipids and liver function abnormalities, and school physical education classes can not pass, in this case, even if the study is good, but also the former work, can not pass Chinese and college entrance exams. Although the child’s diet is restricted and exercise is increased, it often does not solve the problem. In fact, many parents often ignore a problem, is the child’s skin pigmentation problem, many children have appeared behind the neck or underarm skin pigmentation, serious will also affect the limbs and the whole body, parents often think it is the sun or normal phenomenon, even if not clean, but also do not think it is a pathology, in fact, this is a typical morbid obesity, such as not timely treatment, not only obesity can not be controlled In fact, this is a typical morbid obesity, if not dealt with in time, not only obesity can not be controlled, but also fatty liver, diabetes, menstrual disorders and other diseases, often these children already have hyperinsulinemia, through diet and exercise control, sometimes with little effect, must be through medical intervention, reduce its insulin level, improve insulin sensitivity and improve the inflammatory state of the body, in order to solve the problem from the more basic, such as delayed treatment, will affect the child’s life, if corrected in time, completely It is possible to prevent the problem before it happens. Acanthosis nigricans is a kind of hyperkeratosis, symmetrical velvety thickening, hyperpigmentation and even wart-like protrusion of the skin, mainly involving the axilla, the back of the neck, the flexor surface of the skin, the groin and the umbilicus. There are many causes of acanthosis nigricans, such as malignant tumors, endocrine diseases, obesity, drugs and certain genetic-related diseases. Epidemiological studies have found that the incidence of acanthosis nigricans in the general population is 7%, while in the obese population the incidence is 74%, obesity has become the most common cause of acanthosis nigricans, and acanthosis nigricans is the most common skin manifestation in the adolescent obese population, and is a skin sign of insulin resistance in adolescent obese patients. And adolescent obese patients with acanthosis nigricans have more pathological changes and inflammatory status than those with obesity alone, such as high BMI, ultrasensitive C-reactive protein and fasting insulin, and insulin levels were found to be significantly higher in the AN group after giving glucose load after OGTT test, so AN is closely related to hyperinsulinemia in adolescent obese patients, and AN can be used as a judgment of cardiovascular disease risk in obese children. AN can be used as a valid clinical indicator to determine the risk of cardiovascular disease in obese children. Dyslipidemia is also more common in obese children with acanthosis nigricans, manifested by high plasma triglyceride levels and low HDL levels, and patients with AN are more likely to have a combination of dyslipidemia associated with atherosclerosis, which can be used to assess the degree of metabolic disorders in obese children. Therefore, parents are advised to pay attention to obese children who overeat and are prone to hunger, and if they find obvious darkening and pigmentation in the back of the neck, armpit or groin, they should seek medical attention and timely treatment so that our next generation will have a healthy body and a good mind.