In China, the prevalence of infertility is increasing and has exceeded 15%, and at least half of these infertility cases are related to male factors. In other words, 15 out of every 100 fertile couples suffer from fertility difficulties, and at least 7 of these couples have fertility difficulties due to male factors. Male infertility has become a major disease that affects men’s physical and mental health, family marriage and social stability. With the development of assisted reproductive technology (artificially assisted conception), it is possible for most male infertility patients to have their own offspring. Assisted reproductive technology is the abbreviation of human assisted reproductive technology (ART), which mainly includes two categories: artificial insemination and IVF (in vitro fertilization-embryo transfer). Many infertile couples think that the offspring born through assisted reproductive technology (ART) is the best, that ART is eugenic, and that ART can choose the sex to have a boy, but these are actually wrong and one-sided ideas. From the perspective of eugenics, the healthier the offspring will be by the closer to natural methods, the lower the risk of suffering from malformations and other diseases. This is because the natural combination of sperm and egg allows for superior selection of sperm, and only the best sperm can fertilize the egg, and the quality of embryos through natural fertilization methods is relatively good. The artificial in vitro manipulation of sperm, eggs and embryos during assisted reproduction techniques (artificially assisted conception) may increase the risk of unhealthy offspring. Assisted reproductive technology (artificially assisted conception) also does not allow for casual sex selection, and cannot be used to have a boy if you want or a girl if you want. Moreover, the more natural the method of reproduction, the less it costs. Therefore, the World Health Organization (WHO) recommends the “downgrading principle” in the treatment of infertility, choosing the natural, simple and inexpensive fertility methods (natural intercourse and intrauterine insemination) first, and then the more complex and expensive fertility methods (in vitro fertilization). The most natural and healthy way to have children is natural intercourse, followed by intrauterine insemination, and then IVF. Under the premise that the female reproductive system is normal, the following is a selection of male fertility methods from the perspective of eugenics. 1. Natural sexual intercourse is the most “eugenic”. The first thing to do is to improve the sperm quality of male infertility patients through medication and other methods, and try to have natural intercourse while undergoing treatment. The second, adequate and regular sex life, for couples trying to conceive naturally, is also very important. The couple should work closely together and insist on having sex every 3 to 4 days as long as the female partner is not menstruating. The female partner should preferably monitor ovulation with ovulation test strips and other methods and increase the number of intercourse sessions when the female partner is ovulating to increase the chances of conception. The better the sperm quality (sperm quantity, vitality and function) of the male partner, the higher the success rate of natural intercourse and fertility. It is best for male infertility patients with poor sperm quality to improve their sperm quality through medication and other methods under the guidance of a male physician. 2. Intrauterine insemination (IUI) has become the preferred method of assisted reproductive technology (artificially assisted conception) for infertile women with patent fallopian tubes. First of all, the sperm quality of male infertility patients should be improved through medication and other methods, and then IUI is performed on the day of ovulation of the female partner. After the male partner’s semen is washed and optimized in vitro, the doctor uses an injection device to inject the part of sperm with high motility into the uterine cavity of the female partner, and the sperm and the egg combine naturally to form an embryo in the female partner’s body. The better the sperm quality (sperm count, motility and function) of the male partner, the higher the success rate of artificial insemination. Male infertility patients with poor sperm quality are best advised to improve their sperm quality through medication and other methods under the guidance of a male physician. 3. The first generation of IVF (in vitro fertilization-embryo transfer, IVF-ET) is a technique in which the sperm and eggs of the couple with infertility are removed, fertilized and developed into embryos in the culture medium of an in vitro culture dish, and then selected and transferred into the uterine cavity of the patient to allow the embryos of good quality to implant and achieve pregnancy. It usually takes 3 to 6 failed IUIs before the first generation of IVF (IVF-ET) can be performed. The better the male partner’s sperm quality (sperm count, viability and function), the higher the success rate of IVF. Male infertility patients with poor sperm quality are best advised to improve their sperm quality through medication and other methods under the guidance of a male physician. 4. Second-generation IVF (intracytoplasmic single sperm injection, ICSI) involves the direct injection of a single sperm into the oocyte plasma to fertilize it with the help of a microscopic operating system. This technique has the potential to cause unknowable damage to the egg and to pass on disease-causing genes to the next generation, and the offspring obtained through this technique have a higher incidence of sex chromosome abnormalities and hypospadias than the general population. Given the high risk of this technique, ICSI is only used for male infertility in patients with severe oligo-, oligo-, and teratozoospermia and sperm acrosome abnormalities who have failed treatment, who have no sperm in their semen but have sperm on testicular biopsy, and when the first generation of IVF-ET is not fertilized or has a low fertilization rate. Male infertility patients with poor sperm quality should preferably improve their sperm quality through medication and other methods under the guidance of a male physician, and try second-generation IVF (ICSI) technology if the treatment is not satisfactory. 5.Third generation IVF (Preimplantation Genetic Diagnosis, PGD) is to avoid the birth of children with genetic defects, based on the second generation IVF (intracytoplasmic single sperm injection, ICSI) technology, combined with embryo microscopic manipulation, molecular genetics and molecular biology and other technologies, one or two cells are removed from the obtained embryos for genetic diagnosis, and healthy embryos are selected for transfer into the The embryos are selected for transfer into the uterine cavity. In vitro operations such as intracytoplasmic single sperm microinjection and removal of one or two cells from the obtained embryos increase the risk of unhealthy offspring, so PGD is only used for various genetic disorders of clear etiology, such as thalassemia and chromosomal translocations. In conclusion, it is best for male infertility patients to see a reproductive male clinic first for semen analysis and other tests. Male infertility patients with poor sperm quality should improve their sperm quality through medication and other methods under the guidance of a male physician and try to choose the most eugenic fertility method.