The triad of duodenal ulcers includes the combination of esomeprazole, amoxicillin and clarithromycin. The main causes of the appearance of duodenal ulcers are gastric acid action and H. pylori infection. Clinical treatment involves suppression of gastric acid and eradication of H. pylori, which is the key to the treatment of duodenal ulcer. Esomeprazole has a strong inhibitory effect on gastric acid secretion and is the best drug for acid-related diseases, patient compliance is also better, duodenal ulcers heal faster, and patients’ symptoms disappear quickly, active duodenal ulcer patients are particularly suitable. The antibacterial activity of amoxicillin and clarithromycin is also very good and can effectively kill Helicobacter pylori, and the combination of these three can play a very good therapeutic role. However, after a duodenal ulcer is cured, it is important to review the duodenoscopy once every six months to determine whether the patient’s duodenal ulcer is truly cured.