Scleroderma, also known as systemic sclerosis, is a common and multifaceted disease in rheumatology. It is a rheumatic immune disease mainly characterized by hardening and thickening of the skin. It is more common in women, and most of the onset is between 30 and 50 years old. Clinical manifestations: The most common initial manifestations of scleroderma are Raynaud’s phenomenon and insidious swelling of the extremities and face, with gradual thickening of the skin of the fingers. The first symptom is Raynaud’s phenomenon in about 70% of patients. Polyarthrosis is likewise a prominent early symptom. Gastrointestinal disorders (heartburn and dysphagia) or respiratory symptoms are occasionally the first manifestations of the disease. Patients may have irregular fever, loss of appetite and loss of body mass before the onset of the disease. In almost all cases, skin sclerosis starts in the hands, with shiny, taut fingers and back of the hands, disappearance of finger folds and sparse sweat, followed by involvement of the face and neck. Patients have a feeling of tightness in the upper chest and shoulders. Transverse thick streaks appear in the front of the neck ding, and when tilting the head, the patient feels tightness of the skin of the neck, which is rarely seen in other diseases. Facial skin involvement may present as a mask-like appearance. There are radiolucencies around the mouth, thinning of the lips, and a pointed nose. There may be hyperpigmentation or depigmentation of the affected skin. Skin lesions may be limited to the fingers (toes) and face. The skin lesions may be confined to the fingers (toes) and face, or may extend centripetally, involving the upper arms, shoulders, forehead, back, abdomen, and lower extremities. Some may involve the entire body within a few months, some may progress gradually over several years, and some may progress intermittently. Patients may also experience joint pain and muscle pain. The digestive system is mainly involved in the esophagus, which simply means that the esophagus becomes hard and swallowing becomes difficult and painful. If the small and large intestines are involved, abdominal pain, diarrhea and constipation may occur. The lungs and heart can also be involved, such as pulmonary fibrosis, pulmonary vascular inflammation, cardiac fibrosis, etc. Patients will have shortness of breath, chest tightness and other symptoms, once the lungs and heart problems should be more careful. The diagnosis of scleroderma is mainly clinical symptoms combined with laboratory test results, when the patient has the above symptoms, especially with Raynaud’s phenomenon or hardening of the skin on both hands, it is necessary to go to the rheumatology department of a large local hospital for timely consultation and timely treatment. Treatment drugs, mainly symptomatic drugs and immunosuppressive drugs to control the disease, all need to be reasonably matched with drugs by rheumatologists, while the earlier the treatment, the better the effect.