Hirudin is a substance with natural anticoagulant effect found in leeches, which can dissolve blood clots caused by vascular plaques to a certain extent, and also prevent the formation of blood clots on plaques and coronary artery occlusion and other conditions, and is commonly used in the treatment of cardiovascular and cerebrovascular diseases, platelet deficiency, etc. Common drugs containing hirudin include cerebrohematocrit oral liquid and astragalus capsule, which are suitable for stroke, cerebral thrombosis, hyperlipidemia and other diseases. Adverse reactions of hirudin are relatively rare and most patients do not suffer from allergies, but if patients have plaque in their blood vessels, they need to go to a regular hospital for treatment instead of using hirudin without authorization to avoid adverse reactions. Instead, under the guidance of a doctor, leechin can be used to dissolve the vascular plaque and attention should be paid to regular rechecking of prothrombin. If there are problems with the test results, it is necessary to promptly consult the doctor whether to stop, change or adjust the dosage of the medication. In addition, patients with plaque in blood vessels should pay attention to the adjustment of diet and living habits, such as avoiding foods high in oil, sugar and salt, as well as quitting smoking and limiting alcohol, and paying attention to rest, so as to reduce the formation of plaque. In addition, such patients can also use other medications, such as statin lipid-lowering drugs, aspirin, etc. to stabilize the plaque, or through interventional or surgical treatment.