Chronic disease caused by viruses, alcohol, drugs, autoimmunity, genetic metabolism and other factors, with inflammation and necrosis of hepatocytes and liver fibrosis as the main pathological changes, with histological changes and abnormal biochemical tests lasting for more than 6 months. Under the action of viruses, alcohol, drugs, autoimmune and other pathogenic factors, hepatocytes undergo necrosis and inflammation, and collagen-producing hepatic mesenchymal cells (mainly hepatic stellate cells) are activated, resulting in an imbalance between the proliferation and degradation of extracellular matrix such as collagen, which leads to abnormal deposition of fibrous connective tissue in the liver, leading to liver fibrosis in mild cases and structural changes of liver lobules, pseudobullet formation and progression to cirrhosis or even liver cancer. Common chronic liver diseases include the following major categories: 1, chronic hepatitis B (Chronic hepatitis B): previous hepatitis B virus infection for more than six months and chronic hepatitis clinical manifestations, most patients have a family history of hepatitis B aggregation. Some patients with chronic liver disease, although the first onset of chronic liver disease, but the actual acute exacerbation of chronic liver disease, at this time, according to clinical manifestations, laboratory tests, imaging, liver biopsy and other comprehensive analysis can make the diagnosis of chronic hepatitis B. 2, chronic hepatitis C (Chronic hepatitis C): refers to the previous hepatitis C virus infection for more than six months and has the clinical manifestations of chronic hepatitis, some patients have a history of blood transfusion, blood products exposure, unclean injection history, oral invasive treatment history. 3, alcoholic liver disease (Alcoholic liver disease): long-term alcohol consumption for more than 5 years, equivalent alcohol amount ≥ 40g/d for men and ≥ 20g/d for women, combined with clinical symptoms, biochemical and imaging tests and exclude viruses, drugs and other factors, alcoholic liver disease can be diagnosed, clinical types include mild alcoholic liver disease, alcoholic fatty liver, alcoholic hepatitis, alcoholic alcoholic liver fibrosis, and alcoholic cirrhosis. The formula for calculating the amount of alcohol: alcohol (g) = volume of alcohol consumed (ml) x alcohol content (%) x 0,8 (alcohol specific gravity) 4. Non-alcoholic fatty liver disease (Non-alcoholic fatty liver disease): a clinicopathological syndrome characterized by diffuse hepatocellular macrovesicular steatosis in addition to alcohol and other definite liver-damaging factors, often with weight Overweight and/or visceral obesity, elevated fasting glucose, dyslipidemia, hypertension and other components related to metabolic syndrome, combined with abnormal liver function and ultrasound suggesting fatty liver can be clearly diagnosed. This includes non-alcoholic simple fatty liver, non-alcoholic steatohepatitis (NASH), and NASH-related cirrhosis. 5, autoimmune liver disease: including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC). AIH is mainly elevated ALT, AST, often positive anti-nuclear antibody, anti-smooth muscle antibody, anti-liver and kidney microsomal antibody; PBC is mainly elevated ALP, GGT, anti-mitochondrial antibody, M2 subtype positive; PSC is common in middle-aged men, mostly accompanied by inflammatory bowel disease, mostly manifested as right upper abdominal discomfort, weakness, skin itching, jaundice, confirm the diagnosis requires ERCP or MRCP. 6. Drug-induced liver injury: long-term use of certain drugs such as methyldopa, methotrexate and other drugs can cause chronic drug-related liver damage, which can even progress to cirrhosis. In recent years, we have also reported many cases of hepatic vein occlusion caused by the use of traditional Chinese medicine “Tu San Qi”, with jaundice, hydrothorax, ascites, esophageal varices, splenomegaly and other symptoms similar to “cirrhosis”, so detailed questioning of the history of drug use (including some health products and herbal medicines) is important for the diagnosis of this disease. Therefore, it is important to ask about the history of medications (including some health products and herbal medicines) for the diagnosis of this disease. How to treat chronic liver disease? First of all, patients should be reminded to eat properly, combine work and rest, stop drinking and smoking, take medication regularly, and have regular follow-ups. Secondly, treatment can be carried out in the following aspects: 1. Treatment for the cause: active antiviral treatment for chronic hepatitis B and C. Patients with alcoholic liver disease should abstain from alcohol. Patients with non-alcoholic fatty liver disease should emphasize reasonable diet, moderate exercise and control weight to the ideal level. Patients with autoimmune liver disease should consider whether to give immunosuppressive therapy according to their condition. Patients with drug-related liver injury should discontinue drugs suspected of causing liver damage. For drugs that treat important diseases and cannot be discontinued at will, drugs without liver damage or with less liver damage can be chosen instead. 2.Hepatoprotective therapy: including hepatoprotective and enzyme-lowering drugs (glycyrrhizin, dicyclomine, silymarin), anti-yellowness drugs (adenosylmethionine, herbal blood-activating preparations such as compound salvia injection or Chuanxiongzin hydrochloride), and drugs to promote detoxification function (reduced glutathione, polyenylphosphatidylcholine). 3.Immunomodulatory therapy: mainly used for patients with chronic viral hepatitis (thymosin α1, thymopentin). 4.Anti-fibrosis therapy: compound turtle shell soft liver tablet, Fu Zheng Hua Yu capsule, He Luo Shu Liver tablet.