The manifestations of headache are not uniform and often have their own characteristics depending on the cause.1. Onset: Acute onset with fever is often due to infectious diseases. Acute headache that persists without decreasing, with varying degrees of impaired consciousness without fever, suggests intracranial vascular disease (such as subarachnoid hemorrhage). Long-term recurrent headache or throbbing headache of China-Japan Friendship Hospital National Pain Treatment Center Yang Keqin is mostly due to vascular headache (such as migraine) or neurological function disorder. Chronic progressive headache with symptoms of increased intracranial pressure (such as vomiting, bradykinesia, optic nerve papilledema) should be noted as intracranial occupying lesions. Chronic headache in young adults without increased intracranial pressure, often due to anxiety and emotional tension, is mostly myoconstriction headache (or tension headache). 2. Headache site: Knowing whether the headache site is unilateral, bilateral, forehead or occipital, local or diffuse, intracranial or extracranial has important value for the diagnosis of the cause. For example, migraine and cluster headache are mostly on one side. The headache of intracranial lesions is often deep and diffuse, and the headache site of deep intracranial lesions does not necessarily coincide with the lesion site, but the pain mostly radiates to the ipsilateral side of the lesion. In hypertension, the headache is usually in the frontal area or the whole head. Headaches from systemic or intracranial infectious diseases are more likely to be whole head pain. Subarachnoid hemorrhage or cerebral crepitomyelitis has neck pain in addition to headache. Ophthalmogenic headaches are superficial and confined to the orbit, forehead, or temporal region. Nasogenic or odontogenic headaches are also superficial. 3. Degree of headache: The degree of headache is generally divided into mild, moderate and severe, but there is no parallel relationship with the severity of the disease. Severe headache is usually seen in meningitis, migraine, increased intracranial pressure, glaucoma, hypertensive crisis, and various neuralgia. Headaches caused by brain tumors are mostly moderate or mild.4. Nature of headache: Headaches of hypertensive, vascular and febrile diseases are often pulsating. Sometimes neurofunctional headache is also intense. Neuralgia is mostly electric shock-like pain or stabbing pain, and muscle contraction headache is mostly heavy pressure, tightness or pincer-like pain. 5. Time and duration of headache: Some headaches can occur at specific times. For example, intracranial occupying lesions often intensify pain in the early morning. The headache of sinusitis also often occurs in the early morning or morning. Cluster headache often occurs in the evening, female migraine is often associated with menstrual period, and headache of brain tumor is mostly persistent and may have a remission period of varying length.6. Factors that aggravate, alleviate or excite headache: Coughing, sneezing, shaking head and bending over can aggravate intracranial hypertensive headache, vascular headache, intracranial infectious headache and brain tumor headache. Cluster headaches may be relieved when upright. Low head can worsen sinusitis headache. Headache due to acute inflammation of the cervical muscles may be aggravated by neck movements; headache due to chronic or occupational cervical muscle spasm may be gradually relieved by active massage of the cervical muscles. Migraine may be relieved by the application of ergotamine.