Studies have shown that 5%-15% of newborns of HBsAg-positive pregnant women fail blockade and become chronically HBV-infected, even after combined immunization with hepatitis B vaccine and hepatitis B immune globulin (HBIG). ), neonatal factors (e.g., genetic factors, immune function), and other relevant factors (e.g., immunization strategy, timeliness of vaccination, delivery mode of the pregnant woman, feeding mode). HBV DNA levels in pregnant women were associated with the success of hepatitis B vaccine immunization blockade in infants at 7 months of age.