Why is it drug resistant? Genetic mutations are common in viruses during replication. And oral antivirals exert selective pressure on the virus, prompting the emergence of drug-resistant mutations. How can drug resistance be prevented? 1. For patients who do not need treatment (immune tolerance phase or low replication phase), try to avoid treatment. 2, Interferon has the advantage of not inducing drug resistance. 3, analysis of the patient’s condition , choose the right time to use drugs. 4, the combination of drugs or the use of high genetic resistance barrier drugs. 5, accurate dialectical evidence, according to individual selection of Chinese medicine.