With the improvement of living standards, people are increasingly concerned about their own health, mild abnormalities of liver function in the past in the outpatient hepatoprotective therapy to return to normal, but also do not get to the bottom of the matter, and a small number of people can not figure out what is the cause of a muddled account. Recently, we have admitted some patients with recurrent liver function damage, and after magnetic resonance examination, it was found that many of them were due to obstruction of the lower end of the common bile duct caused by choledocholithiasis, which led to poor bile outflow, thus causing liver function damage. There are also some patients who have been treated as chronic hepatitis, and as a result, liver function abnormalities are always recurring, which adds endless mental stress and distress to the patient’s life. There are also some people who have been suffering from intermittent epigastric pain and discomfort for many years, and they have been treated as gastritis in the hospital, but the symptoms can never be completely relieved, and the pain and illness follow them, which brings endless troubles to the patients. After further MRI cholangiopancreatic imaging examination, it was confirmed that the intermittent obstruction was caused by stones in the lower end of the common bile duct, and the symptoms were completely relieved after minimally invasive surgery to remove the stones without opening the abdomen. Cholelithiasis is an old and common disease. Domestic reports of coexisting stones in the gallbladder and common bile duct account for 5% to 29% of gallstone cases, with an average of 18%. Overseas reported gallbladder stones in patients with common bile duct containing stone rate of 10% ~ 15%, and with the prolongation of the course of gallbladder stones, secondary common bile duct stones relatively more, in recent years, an upward trend. Choledocholithiasis can be from the gallbladder or intrahepatic bile ducts, or primary choledocholithiasis. Primary choledocholithiasis is rare in Western countries and frequent in Eastern countries. Whether primary or secondary, these stones are extremely dangerous when they are repeatedly discharged, or when they obstruct the bile ducts and lead to infection, or when they are combined with inflammatory papillary stenosis, or when they complicate biliary pancreatitis. Smaller gallbladder stones may fall into the common bile duct through the cystic duct and form secondary choledocholithiasis. Stones less than 5 mm can be easily discharged from the body, while larger stones may block the common bile duct, resulting in the liver secreting an average of more than 800 milliliters of bile per day that can not be discharged into the small intestine, resulting in an increase in the internal pressure of the bile ducts, bile reflux resulting in impaired function of the hepatocytes, causing obstructive jaundice and cholangitis. The depth of jaundice varies with the degree of stone incarceration, because the stone in the common bile duct is like a piston, which can go up and down, making jaundice “intermittent”, after all, complete incarceration and obstruction is still relatively rare. 80% of the people who have persistent epigastric tenderness, which can be radiated to the back, the right epigastric region, or the left epigastric region, resulting in dyspepsia, abdominal distension, anorexia, or nausea and vomiting, which is associated with gastritis and gastric inflammation, or with gastroenteritis. or nausea and vomiting, and is really difficult to distinguish from gastritis or cholecystitis. If the stone blocks the common opening of the bile duct and pancreatic duct, bile flows back into the pancreas, causing acute pancreatitis. Therefore, patients with choledocholithiasis must be treated in time to avoid the occurrence of critical illnesses such as acute obstructive septic cholangitis and severe pancreatitis, which innocently increase the death rate. The most common clinical B-type ultrasound examination, although inexpensive and non-invasive, the accuracy of the gallbladder stones up to 98%, but due to the influence of the duodenum and other cavity organs, the choledochal stones, especially for the duodenum, the lower end of the lower duodenum choledochal difficult to show. Magnetic resonance cholangiopancreatography (MRCP), on the other hand, is a noninvasive, contrast-free, ductal system that can display the bile and pancreatic ducts well and can show the stones in the common bile duct. Twenty years ago, the clinical are taken to open the abdomen to explore and remove the stone for treatment, not only the hospitalization time is long, the damage is big, but also easy to residual stone, the literature reports that the incidence of residual stone can be up to 10%, the trauma to the patient is still very big, and the patient’s pain is abnormal. Therefore, clinicians have been looking for treatment methods to reduce the residual stone rate and trauma. In recent years, due to the emergence of duodenoscopic retrograde cholangiopancreatography (ERCP) technology, sphincterotomy lithotripsy technology, lithotripsy instruments are more and more sophisticated, physicians in the endoscopic lithotripsy operation skills are more and more superb, endoscopic choledochotomy has gradually replaced the traditional surgical procedure to become the preferred method of treatment of choledochal stones. This is exactly the gospel that the development of modern medicine has brought to the patients. Compared with traditional surgery, endoscopic choledochotomy has the advantages of no anesthesia, less trauma, less pain, faster recovery, better safety and lower cost. It is especially suitable for those patients who are old, weak and sick and cannot tolerate surgery, or those who have had cholecystectomy for residual or recurrent stones in the common bile duct. We hope that when you encounter intractable chronic hepatitis and epigastric discomfort in your daily life, don’t forget that choledochal stones are the culprits, and remember that once choledochal stones are found, regardless of whether they have clinical symptoms or not, they must be treated aggressively, so as to prevent the disease from occurring before it is too late.