High-risk HPV positivity in women generally refers to positive HPV test results for typing, and a positive high-risk HPV test indicates a higher risk of cervical cancer. In males, cells from the coronal area of the penis should be taken to determine the typing. A positive high-risk HPV test indicates a higher risk of condyloma acuminata and penile cancer. HPV17, HPV20, HPV36, HPV38, most of these types will cause malignant tumor lesions when they are positive, women are prone to vulvar cancer, anal cancer, bladder cancer and other diseases, men will suffer from condyloma acuminata, penile cancer, etc.; 2. HPV31, HPV33, HPV35 and HPV39, among which HPV16 and HPV18 are the most common pathogenic types and are the main viruses causing cervical cancer in women, which need to be confirmed by TCT and pathological examination. High-risk positive for the above viruses also increases the chance of rectal cancer, oral cancer and tonsil cancer, so further treatment is recommended according to medical advice. There is no specific drug for this type of virus infection, most male patients can cure themselves, while female patients are recommended to be treated with recombinant human interferon and laser, cryotherapy, or surgical excision under the guidance of doctors. Patients need to regularly test the number of viruses, actively exercise, ensure sufficient sleep, improve the body’s immunity, and actively cooperate with the treatment to turn negative as soon as possible.