In the early stage of scleroderma, Raynaud’s phenomenon, symmetrical skin sclerosis, muscle stiffness, and digestive malady may appear. 1. Raynaud’s phenomenon: when the hands encounter cold stimuli, it will lead to paroxysms of whiteness, coldness and numbness, and the skin of the hands may first turn blue and then flushed. 2. Symmetrical skin sclerosis: due to the deposition of collagen fibers and other extracellular matrix, can cause skin thickening and fibrous ring, which leads to skin tightness and stiffness, generally from the head and face to the limbs to spread the development, and the symmetrical development. 3. Muscle stiffness: due to the hardness of the skin, the surrounding musculoskeletal function will be affected, resulting in muscle stiffness, swelling and pain and other symptoms. 4. Indigestion: Scleroderma can also affect the digestive system, causing symptoms such as bloating and indigestion. Early symptoms of scleroderma should be a cause for concern, and it is recommended that you visit a hospital for a definitive diagnosis and treatment as prescribed by your doctor.