Patients with depression may experience headache, dizziness, etc. Some patients with depression show a variety of physical discomfort of unknown etiology, such as the more common symptoms of dizziness, headache, panic, shortness of breath, shoulder and throat discomfort, back pain, limb pain, back pain, etc. Some patients show panic, palpitations, chest tightness, nausea, vomiting, anorexia, frequent urination, urgent urination, and even some patients show Some patients show symptoms of panic, palpitation, chest tightness, nausea, vomiting, anorexia, urinary frequency, urinary urgency, and even some patients show various symptoms of discomfort throughout the body. After systematic and comprehensive examination in hospital, the organic cause still cannot be found, so patients often suspect that they have a serious disease, accompanied by depressed mood, slow brain response, feeling that living is a burden to the family, low self-esteem, interest and pleasure significantly reduced, and even have the intention that living is meaningless. This state is more common in elderly patients, who often seek help with this kind of physical discomfort as their main complaint. Therefore, for those who have unexplained physical discomfort, accompanied by emotional and thinking activity disorders, the possibility of depression should be highly suspected and systematic and standardized treatment should be carried out.