The onset of gout is closely related to age and gender, with a male to female ratio of approximately 20:1, and gout is more “male friendly”. Historically, gout was once considered a male disease; in modern times, although gout is still primarily a disease of young and middle-aged men, it has received increasing attention in women, especially in postmenopausal women, as the prevalence of gout in women has increased. The gender differences in the development of gout are mainly due to the different changes in blood uric acid levels in people of different genders. The average blood uric acid value in men before puberty is about 196 micromol/liter, but after puberty, the blood uric acid value increases faster in men than in women, and then remains at a peak of about 310 micromol/liter, but after middle age, the blood uric acid value gradually increases, so the frequency of gout attacks also increases, reaching a peak at the age of 50. This is because before menopause, the level of estrogen in women’s body is higher, and estrogen can enhance the resistance of cell membrane phospholipids to uric acid crystallization, and estrogen can also enhance the role of kidney excretion of uric acid. In addition, estrogen itself has the effect of inhibiting the occurrence of arthritis, so it is said that women rarely suffer from gout before menopause, but after menopause, the level of estrogen in the body drops sharply, and the chances of hyperuricemia and gout occurring rise significantly. However, in recent years, due to the development of China’s society, people’s living standards have been improving and their lifestyles and dietary structures have changed greatly. The large intake of high purine diet and the reduction of physical labor have led to a younger incidence of hyperuricemia and gout in women.