Some patients with depression have clinical manifestations different from or even opposite to the common depression: 1. they can still be happy or happy for a while when they meet something happy, instead of being unhappy even when they pick up money; 2. instead of anorexia or weight loss, they gain weight or have an increased appetite; 3. instead of insomnia, they sleep more; 4. instead of reduced volitional activity, they have heavy limbs, like filled with lead; 5. instead of self-blame Instead of self-hatred, sensitivity to interpersonal relationships, especially to rejection and refusal (note: patients can be like this for quite a long time, not just during depressive episodes; this symptom can also be easily misdiagnosed as relationship delusions or delusions of victimization), leading to significant impairment of social, academic, and work functioning. Depression with atypical depressive symptoms is likely to be an underlying bipolar disorder, and one study found that: the sensitivity of predicting bipolar disorder type II based on atypical depressive symptoms was 42% and the specificity was 74%. In terms of treatment, depression with atypical symptoms may be considered as bipolar disorder if treatment as depression is not satisfactory.