In general, it is necessary to determine that syphilis is not infectious before pregnancy can occur. For patients with early syphilis, it is required that pregnancy can be considered after effective treatment, 2-3 years of follow-up, no clinical relapse, no signs of involvement of other organs, negative non-spirochete serologic test (RPR), or positive but only at very low levels (RPR < 1:8). If syphilis infection is detected in pregnancy, pregnant women who are found to have syphilis before 20 weeks can be treated with 2 courses of benzathine penicillin and their newborns have a higher rate of syphilis blockade than those who are found to have syphilis infection after 20 weeks and can only be treated with one course. This is why prenatal screening for syphilis sera during pregnancy is essential and necessary. For all pregnant women, RPR serology should be routinely performed in early pregnancy or during the first prenatal visit, and then routine screening in the last 3 months of pregnancy if they are at high risk, to confirm the diagnosis early. If a pregnant woman is found to be infected with syphilis, she should first consult a relevant clinical expert to determine whether to continue the pregnancy according to her condition. Patients who continue pregnancy should be treated with one course of benzathine penicillin during the first 3 months of pregnancy, and another course of benzathine penicillin during the last 3 months of pregnancy, and RPR should be reviewed monthly to observe for recurrence and reinfection. Pregnant women who are allergic to penicillin can be treated with erythromycin instead, but be aware that tetracycline is prohibited. Because erythromycin cannot pass through the placenta, the baby should be retreated with penicillin after birth.