Director of Pingxiang Infectious Disease Society Director of Infectious Disease of Pingxiang No. 2 Hospital Ou Shuqiang Although after nearly a decade of extensive promotion of hepatitis B vaccination and nearly five years of active mother-to-child blockade and other methods of preventing the transmission of hepatitis B, the hepatitis B virus surface antigen (HBsAG) positivity rate of the population in China is still as high as 7.18%, which belongs to the moderately prevalent area of HBV. HBV infection of the human body has a variety of endings, very few are cleared by spontaneous immunity, most of them are harmful to the human body in different forms, including chronic hepatitis B, cirrhosis, carriers of the virus, hepatocellular carcinoma, occult chronic hepatitis B, etc., for the treatment of chronic hepatitis B, cirrhosis and hepatocellular carcinoma we can refer to a variety of guides to standardize the treatment, but for the treatment of hepatitis B virus (HBV) carriers at present to the general public has brought a great deal of confusion! However, the treatment of hepatitis B virus (HBV) carriers currently brings great confusion to the general public, and even some physicians have excessive medical treatment. Below I will talk about how to deal with HBV carriers according to the new domestic and international hepatitis B prevention and treatment guidelines and the actual situation in Pingxiang, as well as our own treatment practice! Ou Shuqiang, Department of Infectious Diseases, The Second People’s Hospital of Pingxiang City I. What is HBV carrier? Refers to HBVDNA and / or hepatitis B two half-positive, normal liver function, liver tissue biopsy without inflammation, fibrosis or inflammation of fibrosis is very mild. II. How to handle? 1. For those who are under 40 years old, have no hepatitis, cirrhosis or liver cancer in their family, have no immune disease or use of immunosuppressants or glucocorticosteroids themselves, and do not abuse alcohol or use drugs that may damage the liver, it is recommended to recheck the liver function, HBVDNA, Hepatitis B two halves, ultrasound, etc., every 3-6 months, and there is no need to use any drugs. 2. For those who are over 40 years old, have no hepatitis, cirrhosis or liver cancer in their family, have no immune diseases or use immunosuppressants or glucocorticoids themselves, and do not abuse alcohol or use drugs that may damage the liver, liver tissue biopsy is recommended, and if there is no inflammation or fibrosis in the liver or it is very mild, the same regular follow-up every 3-6 months will be conducted without any medication for the time being; on the contrary if Inflammation (G) ≥ grade 2 and/or fibrosis (S) ≥ stage 2, it is recommended to choose appropriate antiviral therapy according to viral genotype, viral load, past medical history, family history, economic conditions, nature of work, marriage and childbearing status. 3, the use of immunosuppressants, glucocorticoids; chemotherapy, radiotherapy; regardless of age should be under the guidance of infectious disease specialists for standardized antiviral therapy. 4, in the use of anti-tuberculosis, anti-hyperthyroidism, anti-osteoplasia, lowering sugar and other therapeutic processes should be more closely observed changes in liver function, pay attention to distinguish between drug liver damage or viral liver damage, or mixed liver damage, and according to the degree of liver damage to take appropriate measures to deal with, can be observed, preventive hepatoprotection, anti-viral, adjusting the program, the dose or even discontinue the drug and other treatments. Marriage and childbearing of HBV carriers: generally, it does not affect marriage, but before and after marriage, they should not overwork, drink alcohol, etc. If conditions permit, before pregnancy and conception, they can try the drugs that can not only anti-virus but also enhance immunity with the informed consent of both men and women, and try to reduce or clear the HBVDNA load of both parents, especially the mother’s body, and then stop the drugs for at least 3 to 6 months before pregnancy. -It is safer for mother and baby to get pregnant after 6 months. 6, HBV carriers unintended pregnancy treatment: if unintended pregnancy, we should pay special attention to observation, if the liver function remains normal, it is recommended not to easily use hepatoprotective and antiviral drugs; such as liver function abnormalities in the course of pregnancy must be in the infectious disease specialists to judge the use of drugs with caution; if hepatitis threatens the life of mother and baby, early labor should be induced in a timely manner and active antiviral, hepatoprotective treatment; if liver function is mildly impaired, the use of pregnancy safety A If the liver function is mildly impaired, continue to observe when using pregnancy-safe class AB hepatoprotective drugs; if the pregnancy reaches 32-34 weeks, pregnancy-safe class B antiviral drugs can be used after informed consent to achieve the purpose of protecting the safety of mother and child and interrupting mother-to-child transmission. The above treatment may not be comprehensive, specific problems should be analyzed and dealt with specifically, life safety first!