1, to truthfully tell the dermatologist about the disease, in order to timely diagnosis and treatment, avoid fabricating medical history. 2. Prohibit sexual intercourse during the treatment period to avoid infecting each other. Once the diagnosis is confirmed, those who have sexual contact with them should also be examined at the same time. 3, must be regular treatment, do not indiscriminate treatment, blind use of drugs. Because of the patient’s privacy, some patients are prone to listen to a shot of the spirit or some small advertising business recommended drugs, these are the wrong approach. Please go to the regular hospital for anti-Me treatment in time. Note that a skin test must be done before the first injection of penicillin to find out if there is any allergic reaction. Because the injection will kill a large number of syphilis spirochetes, some early syphilis patients will have a systemic reaction such as high fever, headache and even jaundice within 24 hours, which is called Guilher’s reaction. Once it happens, the consequences are serious. So never inject penicillin by yourself. Because syphilis progresses slowly without obvious symptoms, it is often mistakenly considered cured and treatment is interrupted. However, at this time, the disease is in the incubation period, and it may not only relapse quickly, but also continue to infect others. Therefore, after treatment, please follow the requirements for follow-up. 4. Regularly visit the clinic for review. Usually the symptoms disappear quickly after treatment, and the titer should be reduced at least 4 times in 6 months after treatment. The decrease will be slower for those who have been ill for a long time. Otherwise, it is recommended to check the blood sampling for HIV and neurology consultation for RPR in cerebrospinal fluid. Observation should be done for 3 years. In the first year, check every 3 months; in the second year, check every 6 months; in the third year, check at last. If necessary, check annually.