Fluoxetine can be taken in the absence of contraindications when mild depression or refractory depression is generally reached. Clinically, depression is characterized by three major features: significant depressed mood, slowed thinking and slowed movement, two of which are usually met to be diagnosed as mild depression. Refractory depression is defined as depression that has been poorly treated or poorly tolerated with tricyclic antidepressants, sertraline and other medications, and can then be treated with fluoxetine. The negative mood manifested by depression is closely related to the deficiency of 5-hydroxytryptamine in the brain. Fluoxetine is a 5-hydroxytryptamine reuptake inhibitor, and its antidepressant effect is mainly reflected in its ability to bind to some 5-hydroxytryptamine receptors, reducing 5-hydroxytryptamine “recycling” and increasing its concentration, relieving the symptoms of 5-hydroxytryptamine deficiency, and ultimately achieving antidepressant effects. Fluoxetine is a prescription psychotropic drug, so you should consult a psychiatrist before taking it, and take it under the doctor’s guidance to avoid self-medication, increase, decrease or stop the drug, which may cause some side effects, such as nausea, vomiting, pain, rash, etc. Moreover, taking antidepressants such as fluoxetine alone cannot completely control the development of depression, but also needs to be combined with comprehensive treatment such as psychotherapy, which is relatively more effective. In addition, there are some patients who are not suitable for fluoxetine, such as patients with a history of epilepsy, a history of bipolar disorder, acute heart disease, bleeding tendency, or depression with suicidal tendencies, especially women during pregnancy, breastfeeding or children, if there is a depressive condition, the drug should be used with more caution.