The main causes of dialysis pain are as follows: First, it is common in patients who have just started dialysis and is called dialysis imbalance syndrome, which may manifest as headache. This is due to the change in osmotic pressure after the toxins have been removed from the body of a patient on dialysis, which causes headaches. Second, headaches in dialysis patients are common in patients with hypertension or hypotension. Dialysis patients often have a combination of hypertension, which can lead to pulsating vascular pain. Some patients may also have headaches caused by insufficient blood supply to the brain due to volumetric hypotension after water removal after dialysis. Third, dialysis patients often have cerebrovascular accidents, combined with cerebral hemorrhage or cerebral infarction or cerebral hemorrhage after which dialysis pain may occur.