Patients with chronic liver disease should abstain from smoking, alcohol, exertion, emotional excitement, and prohibit or cautiously use hepatotoxic drugs; prevent infections such as lung infections, urinary tract infections, intestinal infections, and abdominal infections. Patients with chronic hepatitis B should not stop using antiviral drugs or reduce the dosage of antiviral drugs at will. The prevention of liver failure, first of all, emphasizes the prevention of etiology: 1. For patients with chronic hepatitis virus infection, they should do regular annual check of liver function and hepatitis B virus replication status, find abnormal liver function, and take timely and effective treatment measures under the guidance of a specialist. Patients with chronic hepatitis should be hospitalized in a timely manner once jaundice appears and be alert to liver failure; 2. Patients who have been treated with oral antiviral drugs should not discontinue the drugs without authorization, once the drugs are discontinued, it will cause a large number of virus replication and the immune response caused will be acute liver failure. It is important to regularly recheck liver function and hepatitis B virus quantification to understand whether there is viral mutation, and adjust the treatment plan in time once it appears. The criteria for stopping medication should be implemented in accordance with the spirit of the guidelines; 3. For alcoholics, abstinence from alcohol is necessary and should be insisted upon; 4. Drugs should be used with caution, and Chinese medicine should not be ignored in common drug-related liver failure.