I. What is glioma? Gliomas are the most common primary cranial tumors due to cancerous transformation of glial cells in the nervous system (brain and spinal cord). They mainly include astrocytoma, oligodendroglioma, mixed glioma, and ventricular meningioma. Is glioma malignant or benign? Gliomas are broadly classified into two categories in terms of biological signs and symptoms. 1. Low-grade gliomas (WHO grade 1-2) are well differentiated, with low malignancy and relatively good prognosis. 2. 2.High-level glioma (WHO grade 3-4), low differentiation, malignant tumor, poor prognosis. What are the clinical manifestations of glioma? 1.General symptoms, headache, nausea, vomiting and other high cranial pressure symptoms. 2, local symptoms, hemiparesis, aphasia, ataxia and other neurological signs. How to diagnose glioma? Head CT and MRI scanning plus enhancement can be clear. How to treat glioma? Surgery: Remove the tumor as much as possible. Radiotherapy can kill the residual tumor and slow down the growth of tumor in important functional areas. For high-grade glioma, the application of chemotherapeutic drugs can significantly prolong the survival time of patients. 4.Others Some other immunotherapy and biological targeted therapy are not yet clinically conclusive. What is the prognosis of glioma? 1, glioma WHO 1-2 patients, the median survival in 8-10 years; (I surgically treated a patient 18 years after recurrence of re-operation, no hemiplegia aphasia after surgery, as normal) 2, glioma WHO 3 patients, the median survival in 3-4 years; 3, glioma WHO 4 patients, the median survival in 1-1.5 years. It is worth noting that the new radiotherapy and chemotherapy program, can make about 10% of patients survive to more than 5 years. 4. Gliomas are difficult to eradicate and tend to recur. Surgery, radiotherapy and chemotherapy can be performed again according to the patient’s condition. (The following figure shows the comparison of preoperative and postoperative films of a glioma patient in our hospital, who had free movement of limbs without hemiplegia and aphasia after operation) Figure 1 Preoperative MRI showed huge glioma Figure 2 Postoperative total tumor resection (horizontal position) Figure 3 Postoperative total tumor resection (sagittal position) Figure 4 Postoperative total tumor resection (coronal position)