Paraquat is one of the most commonly used herbicides and is widely used. With the increasing use of paraquat, the incidence of paraquat poisoning is increasing. Paraquat poisoning is mainly a living and occupational poisoning, in which oral poisoning accounts for more than 95% of the poisoning. Once poisoned, the consequence is extremely serious, the common lethal dose is about 30-40mg/kg or 20% paraquat liquid 10-15ml, the lethality is about 60%-80%. Many people still can’t recognize the toxicity of paraquat correctly, especially when the oral dose of paraquat is 10-30ml, there are no other obvious symptoms in the early stage except for the oral stimulation of gastrointestinal discomfort, so they can’t pay attention to it, and don’t deal with it, or only do gastric lavage and liquid infusion. This is a big misunderstanding, leading to the residual in the gastrointestinal paraquat continue to continue to absorb, toxicity continues to appear, until the absorption of lethal amount of critical condition before attention is paid to the fact that it is too late, even if all the existing effective measures, it is difficult to save lives. According to the clinical observation of 120 cases of paraquat poisoning, where early and thorough implementation of gastrointestinal purification and blood purification cases, the rescue success rate is significantly higher than that of those who did not implement. In fact, the reason is very simple, in the current situation of no specific antidote, rapid and great removal of unabsorbed and absorbed poison in the body, as far as possible to make the poison into the tissue less than the lethal amount, is the key to the success of the rescue treatment. If, despite all the measures taken in time, the absorbed amount of the poison still reaches the lethal dose, or even several times the lethal dose, the mortality rate will be very high. However, if effective drug antagonism and strong life support are taken, some cases are still saved. According to the autopsy observation of the patients who died of paraquat poisoning, the stomach wall and intestine of the deceased patients who had gastric lavage during their lifetime still contained higher paraquat ions than all other organs. Based on the observation of 86 patients with oral paraquat poisoning admitted to our hospital on days 2-7 of the illness, almost all of them had blue paraquat visible to the naked eye in their feces on days 2 and 3. With the passage of time, paraquat in the feces gradually decreased, but some of them could still be seen until the 7th day. The situation was more serious in patients who did not have timely gastric lavage or who did not have diarrhea. It can be proved by the above facts that oral paraquat has a slow absorption process in the gastrointestinal tract, and its absorption rate is about 10-15%, and most of it is discharged from the gastrointestinal tract, but the slower the discharge, the higher the absorption rate. Therefore, the gastrointestinal tract purification is very important, if rushed before the absorption of lethal amount, the chance of successful rescue will increase significantly. From this, it can be determined that oral poisoning within 48h there is still a need for gastric lavage, within 5 days there is still a need for diarrhea. Gastrointestinal decontamination commonly used methods are: 1, out-of-hospital treatment: most of the oral paraquat poisoning patients are at home orally, found that should be immediately on the way to the hospital to induce vomiting, stimulate the posterior wall of the pharynx with a finger or an object to cause the vomiting reflex, as soon as possible, vomit out of the paraquat solution in the stomach. If the patient is unable to vomit, you can also drink 300ml of water and then induce vomiting, and so on until vomiting. But still need to go to the hospital to wash the stomach and diarrhea. 2, gastric lavage and diarrhea: routinely insert gastric tube, first wash the stomach with water until the gastric lavage solution is colorless and tasteless, then wash the stomach with 15% activated charcoal solution 2-3 times to adsorb paraquat in the stomach, and then wash the stomach with 15% bleach solution 2-3 times to remove and inactivate the residual paraquat. After washing the stomach, replace the gastric tube, then inject 20% mannitol 200-250ml diarrhea, 1h and then inject 15% activated charcoal 300ml adsorption of intestinal paraquat, 2h and then inject 15% bleaching earth 300ml inactivation of intestinal paraquat, 3h, if not diarrhea, and then give 50% magnesium sulfate 50ml diarrhea. 6h can be repeated again, until the intestinal paraquat After 6h, it can be repeated one more time, until the paraquat in the intestines is completely diarrhea out, and the paraquat solution cannot be seen in the feces or detected in the feces with the naked eye. Most of the patients have to undergo more than 3 times of diarrhea to clean up paraquat in the gastrointestinal tract. 3.Gastrointestinal protection: after gastric lavage and diarrhea, due to the corrosive effect of paraquat and the stimulating effect of rapid gastric lavage and diarrhea, the oral cavity and gastrointestinal tract may have different degrees of damage. The manifestations are hemorrhage, edema, decay, ulceration of oral mucosa, abdominal pain, nausea, vomiting, etc., and severe cases can be accompanied by gastrointestinal bleeding. Treatment: 1), strong antacid such as Losec and other 40mg bid. 2), gastrointestinal mucosal protective agents: such as aluminum sulfate gel and Yunnan Baiyao oral. 3), bleeding can be local or systemic application of hemostatic agents. 4), oral erosion can be used in the Jinda liquid (epidermal growth factor) spray and wet burns cream coating. 5), the oral mucous membrane can be used to protect the mucous membrane. 6), the oral mucous membrane can be used to protect the mucous membrane. 7), the oral mucous membrane can be used to protect the mucous membrane of the stomach and intestines.