The annual incidence of liver cancer in China is more than 300,000, accounting for about 55% of the global liver cancer patients, and the high death rate of liver cancer has become a serious threat to the health of our people. The diagnosis and treatment of liver cancer requires technical means from multiple disciplines, such as hepatology for hepatitis, interventional vascular treatment, surgery for surgery, radiotherapy for radiotherapy, etc., which objectively requires multidisciplinary collaborative treatment. In 2011, Southern Hospital established the Multidisciplinary Collaborative Group for Liver Tumor, taking the Liver Tumor Ward of Liver Disease Center as a platform to gather multidisciplinary experts and provide patient-centered “one-stop” services from diagnosis to treatment. The multidisciplinary collaborative group of liver cancer specialists comes from the liver disease center (infection medicine), medical oncology, hepatobiliary surgery, interventional medicine, imaging center, radiotherapy, gastroenterology, traditional Chinese medicine and pathology. The multidisciplinary experts are integrated into the daily check-ups, and multidisciplinary expert consultations are held every week to gather the experience of the whole hospital and “tailor-made” treatment plans for newly admitted patients or patients with difficulties. Since its establishment, the MDT team of liver tumor has served nearly 1,000 patients from all over the country and has been generally praised by patients and colleagues. Multidisciplinary expert consultation to avoid overtreatment Multidisciplinary expert consultation to avoid overtreatment Multidisciplinary collaboration is easy to be misunderstood as implementing different treatments for patients from different disciplines, but in fact, it is not. The multidisciplinary collaboration model is precisely designed to reduce overtreatment. In this way, inappropriate examination and treatment, i.e. over-treatment, can be avoided. It is the consensus and general trend of experts at home and abroad to realize standardized treatment of liver cancer through multidisciplinary collaboration model of liver tumor. Scope of diagnosis and treatment: primary liver tumors; intrahepatic metastases; other occupying lesions of the liver.