Mixed anxiety-depressive states often have the following manifestations: 1. sleep disorders: difficulty falling asleep, early awakening, shallow dreams, no sense of recovery after waking; 2. anxiety symptoms: often inexplicable tension, uneasiness, irritability, irritability; fear, anxiety; 3. depressive states: easy fatigue, weakness; emotional, often crying or aggravation; loss of interest in the schedule life, no sense of pleasure; poor concentration, memory (1) Neurological symptoms: headache, dizziness, tinnitus, tinnitus, numbness in the face, lips, hands and feet, tightness or foreign body sensation in the throat; (2) Respiratory symptoms: difficulty in breathing or breath-holding, hyperventilation; (3) Gastrointestinal symptoms: abdominal pain, bloating, constipation, diarrhea, decreased appetite, weight loss; (4) Gastrointestinal symptoms: abdominal pain, bloating, constipation, diarrhea, decreased appetite, weight loss. (4) somatic pain or discomfort: head, neck, back and extremities; (5) genitourinary system: frequent urination, urgent urination, loss of libido; (6) cardiovascular system: chest tightness, palpitations, intermittent hypertension, tachycardia, arrhythmia, and even a sense of dying; (7) sympathetic symptoms: dry mouth, excessive sweating, chills or fever in the body.