Pharmacological studies have proved that alcohol can affect drug effects through two ways: firstly, alcohol metabolism in the liver can competitively inhibit or enhance the metabolic enzymes of certain drugs, thus enhancing or reducing the blood concentration of these drugs and affecting their efficacy; alcohol can increase the permeability of cell membranes of tissue cells, which can greatly increase the absorption rate of drugs. Therefore, the use of drugs after drinking will not only affect the efficacy of the drugs, but even cause adverse consequences, which should be noted. I summarize the following types of drugs as an example, to talk about the possible effects of alcohol. 1, sleeping pills Alcohol and sleeping pills have a central nervous system inhibitory effect, and alcohol can increase the absorption of sleeping pills in brain tissue, making the amount of drugs in nerve cells is particularly high, the brain cortical cells will soon turn into a state of inhibition, if people take sleeping pills before and after drinking alcohol, may lead to coma or even death. 2, hypoglycemic drugs Alcohol and hypoglycemic drugs both have the effect of inhibiting the absorption of sugar and sugar xenobiotic, while using will make the blood sugar drop too fast, and even let people appear hypoglycemic coma. At the same time, alcohol enhances microsomal enzyme activity and shortens the half-life of oral hypoglycemic drugs in the blood, which affects their efficacy. In addition, chlorosulfonylurea and alcohol together can cause severe headache, nausea and vomiting, vertigo and other symptoms; metformin oral hypoglycemic drugs and alcohol meet in the human body, there is a risk of acidosis. Therefore, many people use high sugar, should pay attention to the occurrence of low blood k. 3, antibiotics Pioneer (cephalosporin) drugs and wine taken at the same time can appear headache, nausea, vomiting, vertigo and other symptoms. 4, antipyretic and analgesic drugs Alcohol can cause a large amount of serum gastrin secretion, antipyretic and analgesic drugs can also increase the secretion of serum gastrin, the combination of the two causes a sharp increase in gastrin concentration, gastric acid secretion, so as to destroy the gastric mucosal barrier, damage the submucosal blood vessels, the risk of gastric bleeding. Therefore, some people use H2 receptor antagonists, but H2 receptor antagonists can accelerate the absorption of alcohol, I think it should be used with caution (discussed below). 5.Anti-ulcer drugs H2 receptor antagonists such as methocarbamol can promote the accelerated absorption of alcohol and cause acute alcohol poisoning with symptoms of alcoholism such as hypersensitivity, confusion and disorientation. 6, anticoagulants Alcohol can affect the competition of coumarin and other anticoagulants to liver enzymes, thus enhancing their anticoagulant effect, leading to a shorter half-life of the drug and affecting its efficacy. 7, anti-tuberculosis drugs The oxidation process of alcohol in the body can produce a large number of free radicals, and the increase of free radicals can damage liver cells. Isoniazid, rifampin and other anti-tuberculosis drugs can increase the hepatotoxicity of alcohol, causing jaundice and liver decompensation. 8, antihypertensive drugs Alcohol has the effect of dilating blood vessels, inhibiting sympathetic nerves and vasomotor centers, and weakening myocardial contractility. If you take blood pressure drugs after drinking, will make small blood vessels more dilated, so that blood volume is further reduced, blood pressure drops suddenly, people will appear postural hypotension or fainting. 9, antidepressants Drinkers taking promethazine, amitriptyline and other tricyclic antidepressants, can enhance the sedative effect of drugs, so that people’s behavior disorders, prone to accidents, such effects are mostly seen in the first few days of drug use.