Acne on the face can be treated with oral minocycline hydrochloride and doxycycline type drugs, which are more effective when taken for a period of time. You can also take clindamycin, but only if you are resistant to the above drugs and if the inflammation is more severe, taking them for a long time will have certain side effects, such as diarrhea and enteritis. For acne with severe nodules and cysts, the above antibiotics can be combined with corticosteroid-based oral medications, such as prednisone, and significant results will be seen within a short period of time. In addition, oral isotretinoin pills can also be taken for sclerosing nodules, cysts, and coalescing acne. It is important to pay attention to the liver and kidney function tests during the medication period, and any abnormalities should be discontinued immediately. Oral zinc glycyrrhiza can also be used as an adjunct treatment to prevent hyperkeratosis of hair follicles, as well as oral Chinese medicine, such as Danshinone capsule, Er Ding granules, Niuhuang Qingxin pill, Fangfeng Tong Sheng Wan, etc.