Recently, there have been many post-school children with prolonged coughs, often with a violent spasmodic cough-like cough, that have been poorly treated with multiple treatments. A large proportion of these may be due to Mycoplasma pneumoniae infection. Mycoplasma pneumoniae is a virus-like microorganism without a cell wall that spreads through respiratory droplets and causes mainly pneumonia, but can also cause many extra-pulmonary injuries. It can develop throughout the year, with a small epidemic every 3-5 years, and is particularly likely to develop in children with a base of allergic disease, such as those with a history of asthma, who are prone to mycoplasma infection and to wheezing episodes after infection. For mycoplasma infections several issues should be noted: 1. Many antibiotics are ineffective against mycoplasma, macrolide antibiotics such as erythromycin are useful against it. But recently found a lot of patients with poor results, which may be related to mycoplasma resistance, may also have a mixed infection, when the addition of three generations of cephalosporin antibiotics are often effective 2, mycoplasma infection is easy to repeat, so under the guidance of doctors with a full course of treatment 3, mycoplasma infection may cause extra-pulmonary damage, so in addition to pneumonia, but also pay attention to the presence of heart and kidney damage.