The main manifestation of manic depressive disorder is that patients have both clinical manifestations of depression and emotional and behavioral manifestations such as anxiety, irritability, impulsivity and injury. The main manifestations of depression are depressed mood, unhappy, easily tired, easily strained, etc., accompanied by attention, memory loss, low self-esteem, slow thinking, slow brain response, and decreased learning and work efficiency, as well as less diet, weight loss, insomnia, accompanied by low self-esteem, self-blame, self-guilt, and in severe cases, negative thoughts. In case of manic-depressive disorder, the person will also be easily anxious, irritable, easily provoked, always quarrels and fights with others over small matters, and in serious cases, the person will not be able to control his or her emotions and even hurt others impulsively. If you have manic depression, it is best to actively treat it, mainly recommending medication, such as taking sertraline, paroxetine, etc. for treatment.