Now, all diabetes treatment guidelines at home and abroad unanimously regard metformin as the first-line drug for type 2 diabetes and the core drug for controlling diabetes worldwide. If there is no contraindication, metformin can be used throughout the diabetes treatment; in contrast, many Chinese diabetic patients believe that metformin has high side effects and hurts the liver and kidneys. The reasons for this may be the following: 1, Chinese people believe in Chinese medicine, that Chinese medicine is natural, no side effects, imported Western medicine instructions will write a lot of precautions, side effects, long eat must have toxicity; 2, there are some sales of other treatment of diabetes products claim that metformin toxic, some television stations in the broadcast claimed to be able to “cure The so-called “experts” in the advertisements of “health products” claiming to “cure” diabetes spread the words of metformin’s toxicity and serious liver and kidney damage, in order to facilitate the sale of their products; 3, metformin has been introduced for more than 50 years, the patent The protection period has long passed, its production and sales are not monopolized by any pharmaceutical companies, the price is cheap, and no manufacturer of metformin will do justice to metformin. So, what kind of drug is metformin and why it has endured for more than 50 years, and is there any other drug that can be updated to replace it? Metformin has strong hypoglycemic effect, wide range of application, single drug does not appear hypoglycemic, whether the patient is overweight or not can be taken, for obese diabetic patients, metformin does show some weight loss effect, the application of metformin can prevent the occurrence of diabetes, children over 10 years old can be used safely. It remains the first-line drug of choice for older diabetic patients, and its lesser risk of hypoglycemia has unique benefits for the elderly. Proven, definitive additional benefits of metformin include cardioprotective effects, improvement of blood lipids, improvement of fatty liver (non-alcoholic), tumor suppression, and treatment of polycystic ovary syndrome, among others. A common side effect of metformin is to cause gastrointestinal reactions, including diarrhea, nausea, vomiting, gastric distention, dyspepsia, and abdominal discomfort, with the vast majority occurring in the first 10 weeks of dosing, and most patients tolerating or resolving symptoms as treatment duration increases. “Start with small doses and gradually increase the dosage”, which is an effective way to reduce adverse reactions at the beginning of treatment. Metformin instructions recommend regular monitoring of renal function in patients over 80 years of age; because some patients with lactic acidosis have combined hepatic impairment, those with liver disease should avoid using this product. So, is metformin toxic to liver and kidney function or not? Because metformin is not metabolized by the liver and does not compete with hepatic P450 enzymes, there is no hepatotoxicity. Just because there is less information on the use of metformin in patients with hepatic insufficiency, it is generally recommended to avoid the use of serum aminotransferase when it exceeds 3 times the upper limit of normal, and patients with mildly high aminotransferase should closely monitor liver function when using it. The reason for this is simply the concern that disease of the liver itself affects normal lactate clearance and causes lactic acidosis, not because metformin has any hepatotoxicity. Although metformin, a good and inexpensive hypoglycemic drug, is suitable for most patients, but should also be applied under the guidance of a doctor, particularly high blood glucose may first choose insulin or / and 2 or more drugs in combination, as soon as possible to make blood glucose standards, so it is recommended that diabetic patients do not self-medication, by a specialist will be integrated systemic conditions to determine a comprehensive treatment plan.